Volume 33 (2019) – Issue 3 – Review of Clinical Pharmacology and Pharmacokinetics-International Edition

1 19ο Συνέδριο Ιατρικής Χημείας: Σχεδιασμός και Ανάπτυξη Φαρμακευτικών Προϊόντων, 20-22 Σεπτεμβρίου 2018, Αμαλιάδα, Ελλάς –
19th Medicinal Chemistry Conference: Drug Discovery and Design, August 20-22, 2018, Amaliada, Hellas

Rev. Clin. Pharmacol. Pharmacokinet. Int. Ed. 33(3): 57-106 (2019)

CONTENTS
J. MATSOUKAS………………….…….…………62
Letter from the Guest Editor
PROKOPIS PAVLOPOULOS, President of Hellenic Republic…………….………………..….64
Speech of of H.E. the President of the Hellenic Republic Mr Prokopios Pavlopoulos at the Opening of 19th Medicinal Chemistry Conference
HARALD ZUR HAUSEN……………….…..……67
Speech of the Nobel Laureate Harald zur Hausen
V. APOSTOLOPOULOS…………………………68
Modern developments in Medical Research: What we have achieved. Next targets
A. ROSTAMI………………………………………..69
IL-27 responsiveness in dendritic cells is essential for antigen-specific tolerance against ongoing CNS autoimmunity
M. ROSTAMI, V. APOSTOLOPOULOS, J. MATSOUKAS………………………………………70
Multiple Sclerosis Research in Greece: targeting clinical trials
A. AVRAMOULI, P. VLAMOS ……………………..72
Protein Misfolding Simulation Tools in Drug Discovery
M. ADAMOPOULOU, C. PAPATHEODOROPOULOS, J. MATSOUKAS …………………..…74
Experimental models in Multiple Sclerosis and neurophysiology: Preclinical studies of citrullinated MBP analogues in Wistar rats
P. ASIMAKOPOULOS…………………………………76
The role of Human Papilloma Virus in Oropharyngeal Carcinoma
E. I. VRETTOS, A. G. TZAKOS…………………77
Design and synthesis of peptide-drug conjugates selectively targeting cancer cells

G. MESSARIS, D. GEORGAKOPOULOS, P. ZAMPAKIS, C. KALOGEROPOULOU, T. PETSAS, G. PANAYIOTAKIS …………………….78
Patient X-ray dose in brain perfusion Computed Tomography imaging
D. DIAMANTIS, A. TZAKOS………………….…80
Rational design of flavonoids based prodrugs triggered by alkaline phosphatase for treatment of metastatic prostate cancer
S. ATHANASOPOULOU, A. KAPNISI, A. LYGERAKI, S. PANTELIOU, C. KONTOYANNIS, M. ORKOULA ………………………………………….81
Monitoring bone reconstruction in fractures of femurs using Raman Spectroscopy
A. KOSTAGIANNI, A. TSIAILANIS , Ε. GIANNOPOULOU, S. PAPPAS, Κ. SIATIS, Α. LAMPROPOULOU, Μ. SAKKA, Α. KOUGIOUMTZI, Ε. MPRIASOULIS, CH.
KALOFONOS, Α. ΤZAKOS……….………….…82
Synthesis of cell penetrating peptides for targeting tumors
MICHAIL V. LYKOURAS…………….…………..83
The use of analytical techniques in drug design
A. BALASOPOULOU, D. KAMPOLIS, M. KRINI, K. SPANOU, A. JOHN, B. R. ALI, M. KANARIOU, N. CONSTANTINIDOU, G. CHROUSOS, E. ROMA, G. P. PATRINOS, T. KATSILA………….84
Exploring the gut-thyroid axis in paediatric cοeliac disease patients of Hellenic origin – a novel immunogenetics strategy
P. NIKOLAOU, I. VARELI, E. DESKOULIDIS, J. MATSOUKAS, A. VASSILAKOPOULOU, I. KOUTSELAS, E. TOPOGLIDIS…………………….86
Use of a novel Graphite/SiO2 hybrid electrode modified with hybrid organic-inorganic perovskites for the determination of losartan
I. PANAGOULIAS, I. AGGELETOPOULOU, S. ANASTASOPOULOU, E. KOUREPINI, D. TZANETAKOS, I. TZARTOS, C. KYLINTIREAS, V. PANOUTSAKOPOULOU, A. MOUZAKI…….88
Molecular pathogenesis of multiple sclerosis. The role of transcription factor Ets-2

I. SOTIROPOULOS………………………………..…90
Neuronal sorting and degradation of Tau protein in Stress and Alzheimer’s disease brain pathologies
M. RODI, ANNE-LISE DE LASTIC, S. ANTONOPOULOU, C. KYLINTIREAS, V.
APOSTOLOPOULOS, J. MATSOUKAS, A. MOUZAKI ……………………………….……..…92
Antigen presentation by tolerogenic dendritic cells: the MOG35-55 -mannan conjugate paradigm. A potential therapeutic vaccine for Multiple Sclerosis
D. SIMOPOULOS……………………….……….94
The Origin of the Chemical Elements
V. TSEVELEKI, T. TSELIOS, I. KANISTRAS, V. APOSTOLOPOULOS, J. MATSOUKAS, L. PROBERT ………………………………………..95
Therapeutic approaches in multiple sclerosis mouse models using mannan-conjugated peptides
K. FALIDA, T. BUND, HARALD ZUR HAUSEN…………………………………………………..96
Search for infectious agents contributing in Breast Cancer and Hodgkin’s Lymphoma
C. CHALIKIOPOULOU, G. P. PATRINOS, T. KATSILA………………………………………….97
Defining the “actionable genome” toward risk assessment for recurrent cardiovascular events

C. CHATZIGIANNIS, A. TZAKOS………..…….98
A theragnostic device with photo regulated drug dosing and cancer microenvironment sensing character
A. KONSTANTOPOULOU, N. ARAVANTINOSZAFIRIS, M. M. SIGALAS………………………..99
Acoustic Ring Biosensor
M. TSIKRIKA, E. TOPOGLIDIS…………………..101
Design and Pilot Manufacturing of electrochemical biosensor for the detection of organic halogen compounds in the water
H. STERGIOPOULOU……………….…….……102
My recent experience at the Cambridge Immerse Summer Programme: the challenge of research in Biosciences
J. HONDRELIS ………………………..…….……103
From Angiotensin to Sartans: A New Generation of anti-hypertensive drugs and their perspectives
C. CHRISTODOULOPOULOS…………….……105
Ομιλία Δημάρχου Ήλιδας

pISSN 1011-6583

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