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Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 25, 2024 - 00:01 |May 3, 2024 Menu, Menu International

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Azelnidipine is a calcium-channel antagonist classified as a “class 2” drug with high permeability and low aqueous solubility. It is used in the treatment of angina pectoris and hypertension without reflex tachycardia. Improvement of the solubility of azelnidipine and increasing drug’s bioavailability can be achieved through the drug encapsulation in solutol / D-α-tocopheryl polyethylene glycol succinate (TPGS) micelles. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 24, 2024 - 23:32 |May 3, 2024 Menu, Menu International

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Ceruloplasmin (CP) is an enzyme that has ferroxidase activity and is important in maintaining iron homeostasis and serving as a copper-transporter in the bloodstream. Beta-thalassemia major (BTM), a common hereditary disorder in Iraq, can affect CP activity in patients with iron overload resulting from frequent blood transfusions in order to sustain haemoglobin levels. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 24, 2024 - 23:11 |May 3, 2024 Menu, Menu International

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Open Access Research Hepatotoxic effects of Stevia rebaudiana leaf extract and commercial stevia on rats: a comparative study Aamer Mousa Ali1,*, Noor Ali Hussein2, Dhafer Jawad3, Hayder H. Abed4, Shereen M. Mekkey5 1Department of Pharmaceutics, College of Pharmacy, University of Babylon, Hillah, Iraq 2Babylon Education Directorate, Ministry of Education, Hillah, … Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 24, 2024 - 22:40 |May 3, 2024 Menu, Menu International

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Gastrointestinal cancers, including stomach, liver, oesophageal, pancreatic, and colorectal cancers, represent more than a quarter of all cancers. Many abnormal gene expressions and dysregulated signalling pathways have been found in human cancer. Cancer often has activating mutations of the KRAS (Kirsten rat sarcoma virus) oncogene. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 23, 2024 - 12:13 |May 3, 2024 Menu, Menu International

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The proceedings of the 1st International Babylon Conference on Clinical and Experimental Pharmacological Research (taking place at the College of Pharmacy of the University of Babylon, in Hillah, Iraq; May 4-5, 2024) are hereby hosted by the Review of Clinical Pharmacology and Pharmacokinetics – International Edition; a journal that has provided a significant service to the international pharmacological community since 1987. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 11, 2024 - 17:31 |May 4, 2024 Menu, Menu International

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Stevia is herbal native to South-America that is renowned for its natural sweet leaves containing stevia glycosides. Our study aimed at examining and comparing the immunomodulatory effects of the Stevia rebaudiana leaf extract and of commercially-available stevia products in rats. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 10, 2024 - 23:41 |May 4, 2024 Menu, Menu International

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Cydonia oblonga is effective against many infections and has medicinal properties that are useful in the treatment of many other diseases. The aim of this study was to elucidate the antimicrobial activity (in the form of anti-adherence and anti-biofilm formation) of the aqueous Cydonia oblonga extract. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 10, 2024 - 22:55 |May 4, 2024 Menu, Menu International

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Alhagi maurorum is one of the many plants that have proven effectiveness in folklore medicine and that are still utilized to treat disease or disorders, thanks to their phytochemical compounds and other secondary metabolites. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 10, 2024 - 22:32 |May 4, 2024 Menu, Menu International

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Bilosomes are nanocarriers that contain bile salts in their vesicular bilayer, thereby enhancing their flexibility and durability in the gastrointestinal tract. Unlike conventional vesicular systems they provide distinct advantages such as streamlined manufacturing procedures, cost efficiency, and improved stability. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

By Helen Plessa | April 10, 2024 - 22:17 |May 5, 2024 Menu, Menu International

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Gastric ulcer is the most common health concern due to alcohol consumption, smoking, and physiological stress. An ethanol-induced gastric ulcer in an animal model resembles the pathophysiology of the human ulcer. Continue reading →