Category Archives: Menu

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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Lower extremity peripheral vascular disease is a typical, rapidly progressive, and disabling condition. In most patients,limb ischemia is detected at late stages of the disease. As a result, they are at high risk of limb loss, which makes acomplete conventional treatment ineffective. In this situation, balloon angioplasty and stenting of lower extremity ar-teries are considered the optimal modern method of treating patients with critical limb ischemia. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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Lutein is a xanthophyll carotenoid that can be found in a divergency of fruits and plants. Its main action is to protecteye health and vision. Its antioxidant properties play a crucial role in eye agitations, in decreasing inflammation, inprotecting the neural tissues from chemical analyzed hypoxia and cell apoptosis. Lutein supplementation inassociation with low-calorie diet had a notable abatement in fat-free mass, visceral fat and serum levels of totalcholesterol and LDL-cholesterol. Lutein may also have a natural anti-cancer effect. This is because foods rich in luteinhave antioxidant activity and oppose inflammation and oxidative stress. The benefits to the literature from this mini-review is that it has summarized the main actions of lutein in the human body. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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Gestational Diabetes Mellitus (GDM) is the most common pregnancy complication, affecting 14% of global pregnan-cies. This literature review emphasizes the importance of developing universal screening and diagnostic criteria inpregnancy. Screening criteria, as outlined by organizations like NICE and WHO, vary, reflecting the ongoing debateabout the most effective diagnostic methods. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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In recent years, the study of medicinal plants’ therapeutic properties has increased due to their effects and biologicalactivities. The Acanthaceae family consists of 242 genera and 3947 species mainly distributed across tropical andsubtropical zones. This family is known to contain a wide range of bioactive compounds, such as, alkaloids, triterpenessteroids glycosides, polyphenols, and polysaccharides. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue1 – Article 7

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Collagen is an excellent biomaterial. Biological characteristics of collagen including biodegradability and weak antigenicity made it a primary resource in medical application. In biomedical field collagen is mainly used as sponges for wound/burn, supplement in rheumatoid arthritis, drug delivery system, controlling material for transdermal delivery and basic matrices for cell culture system due to its ability to stimulate formation of tissue and organ. Moreover, collagen is also applied in tissue engineering including bone defect, tissue regeneration, skin replacement and artificial blood vessels and valves. The article reviews biomedical application of collagen in wound healing, rheumatoid arthritis, drug delivery system, tissue engineering and lung function improvement in pulmonary fibrosis due to viral infection. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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Collagen is an excellent biomaterial. Biological characteristics of collagen including biodegradability and weak antigenicity made it a primary resource in medical application. In biomedical field collagen is mainly used as sponges for wound/burn, supplement in rheumatoid arthritis, drug delivery system, controlling material for transdermal delivery and basic matrices for cell culture system due to its ability to stimulate formation of tissue and organ. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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Proton pump inhibitors (PPIs) are widely prescribed medications for the management of gastroesophageal reflux disease (GERD) and peptic ulcer disease. Despite their efficacy, concerns have emerged regarding their potential adverse effects, particularly in patients with chronic liver disease (CLD). CLD patients often experience gastrointestinal symptoms and may be prescribed PPIs, but the impact of PPI use on liver function and disease progression remains uncertain. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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Diabetes is a common and serious disease. However, the past 50 years have seen a growing ageing population withan increasing prevalence of type 2 diabetes mellitus (DM2). Now, nearly half of all individuals with diabetes mellitusare older adults (aged ≥65 years). Elderly people with diabetes is a heterogeneous group, in many cases the conditionof diabetes is accompanied by other chronic diseases, but also by the ability of the elderly themselves to control theirblood glucose. The therapeutic treatment of elderly diabetic patients must be done with special attention and a lot ofthought. Special importance should be given to exercise with aerobic exercise or alternatively the application of aprogram of progressive increase in muscle intensity (3-5 times a week), as well as training in proper nutrition withparticular emphasis on the Mediterranean diet, which seems to increase survival in adults. Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

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Open Access Editorial Should ultrasound assessment of the endometrium be necessary in patients treated with Tamoxifen? Georgios Iatrakis1,, Stefanos Zervoudis1,2,Angeliki Sarella1, Panagiotis Tsikouras3, Minas Paschopoulos5, Myrsini Balafouta1, Panagiotis Peitsidis 4,* 1 University of West Attica, Athens, Greece 2 Rea Hospital, Athens, Greece 3 University Hospital of Alexandroupolis, Greece 4 Helena Venizelou … Continue reading →

Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Supplementary Issue 1

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Sport performance is the way in which sport participation is measured. It has different aspects, each of which has a number of subcategories. Apart from these, there are some additional elements that are important in the training process, such as nutrition, meal time and supplements, maintaining a healthy weight, hydration, rest and recovery, satisfying body image and well-being. Continue reading →