Smart nanopolymers with the capability to release drugs on demand and in response to specific illness signals, represent a promising avenue in the field of drug delivery. Continue reading
Regulatory B-cells (Breg cells) represent as an important modulator of the immune system and their role is unique in autoimmunity, infection, tolerance to transplants, allergy, and cancer. Continue reading
Cystatin C (CysC) levels in patients with multiple myeloma (MM) have been linked to tumour load and outcomes’ prediction. This study aimed at assessing the diagnostic utility of CysC in distinguishing MM patients from controls and advanced stages of MM. In total, 98 MM patients and 57 healthy controls participated in this cross-sectional case-control study. Continue reading
Burns and wounds destroy the physical skin which is the body’s natural barrier to the external environment. As a result the burned area is prone to infection and colonization by microorganisms. The most common pathogenic colonizing bacterium is Staphylococcus aureus. Continue reading
A straightforward and sensitive method for high-performance liquid chromatography (HPLC) was created in order to separate and identify the di-stereoisomeric mixture of a spiro-oxalidinonic derivative of sorbinil. Continue reading
When bacteria attach to the human body, they have many defense mechanisms. These mechanisms pose a global health risk. Medicinal plants can be used to control such bacterial attack mechanisms. The aim of this study was to assess the antimicrobial potential of an aqueous extract of Salvia rosmarinus and other plant extracts against some clinical bacterial isolates. Continue reading
Azelnidipine is a calcium-channel antagonist classified as a “class 2” drug with high permeability and low aqueous solubility. It is used in the treatment of angina pectoris and hypertension without reflex tachycardia. Improvement of the solubility of azelnidipine and increasing drug’s bioavailability can be achieved through the drug encapsulation in solutol / D-α-tocopheryl polyethylene glycol succinate (TPGS) micelles. Continue reading
Ceruloplasmin (CP) is an enzyme that has ferroxidase activity and is important in maintaining iron homeostasis and serving as a copper-transporter in the bloodstream. Beta-thalassemia major (BTM), a common hereditary disorder in Iraq, can affect CP activity in patients with iron overload resulting from frequent blood transfusions in order to sustain haemoglobin levels. Continue reading
Open Access Research Hepatotoxic effects of Stevia rebaudiana leaf extract and commercial stevia on rats: a comparative study Aamer Mousa Ali1,*, Noor Ali Hussein2, Dhafer Jawad3, Hayder H. Abed4, Shereen M. Mekkey5 1Department of Pharmaceutics, College of Pharmacy, University of Babylon, Hillah, Iraq 2Babylon Education Directorate, Ministry of Education, Hillah, … Continue reading
Gastrointestinal cancers, including stomach, liver, oesophageal, pancreatic, and colorectal cancers, represent more than a quarter of all cancers. Many abnormal gene expressions and dysregulated signalling pathways have been found in human cancer. Cancer often has activating mutations of the KRAS (Kirsten rat sarcoma virus) oncogene. Continue reading
