Τόμος 30 (2016) – Τεύχος 3 – Άρθρο 3 – Review of Clinical Pharmacology and Pharmacokinetics- Διεθνής Έκδοση – Volume 30 (2016) – Issue 3 – Article 3 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

By | | Αθανασία Bαρβαρέσου,Athanasia Varvaresou, Πλήρες Κείμενο στα Αγγλικά - Full Text in English, Σπυρίδων Παπαγεωργίου, Spyridon Papageorgiou, Στατιστική μελέτη - Statistical study
Title Efficacy Tests of Alternative Preservatives in Combination with Phenoxyethanol for Development of Safe Cosmetic Products for Children
Author Athanasia Varvaresou and Spyridon Papageorgiou
Affilations Department of Aesthetics and Cosmetology, Faculty of Health and Caring Professions, Technological Educational Institution (TEI) of Athens, Athens, Hellas
Citation Varvaresou A., Papageorgiou S., : Efficacy Tests of Alternative Preservatives in Combination with Phenoxyethanol for Development of Safe Cosmetic Products for Children, Review Clin. Pharmakol. Pharmakokinet. Int. Ed. 30(1): 79-83 (2016)
Publication Date Accepted for publication (Final Version): November 28, 2016
Full Text Language English
Keywords Alternative preservatives, cosmetics for children, sensitive skin, dermatological safety, Phenoxyethanol, Chlorphenesin, Glyceryl caprylate, Ethyhexylglycerin
Other Terms Statistical study
Summary The aim of this study is to evaluate the antimicrobial efficacy of some alternative preservatives in combination with Phenoxyethanol in order to produce a series of safe cosmetic products for children with sensitive skin. A shampoo, a shower gel and moisturizing body milk for children with sensitive skin were formulated. We used Phenoxyethanol as the main cosmetic preservative because of its very good toxicological profile. The antimicrobial efficacy of Phenoxyethanol was proved to be unsatisfactory regarding the Staphylococcus aureus and Aspergilus niger, when used alone in above formulations. Another traditional preservative such as Chlorphenesin was added to Phenoxyethanol and both microbiological and dermatological tests were successful. A boosting alternative preservative mixture which in not indexed in Annex VI as preservative – alter-native preservative – consisted of Glyceryl caprylate, Glycerin, Caprylyl glycol and Phenyl propanol, was added to Phenoxyethanol in order to achieve both microbiological and dermatological safety of shampoo and shower gel for the children. In case of body milk the alternative preservative, Ethylhexylglycerin, was tested instead of the preservative mixture of Glyceryl caprylate, Glycerin, Caprylyl glycol and Phenyl propanol. The combination of the alternative preservatives i.e. mixture of Glyceryl caprylate, Glycerin, Caprylyl glycol and Phenyl propanol or Ethylexylglycerine with Phenoxyethanol was satisfactory regarding the microbiological challenge tests. The products were also tested for dermatological safety with a 48h patch test. The results were successful and highlighted the usefulness of some alternative preservatives in combination with Phenoxyethanol when both the lowest toxicological potential and the biggest antimicrobial efficacy are required as in the case of the cosmetics for children with sensitive skin.
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