Volume 37 (2023) – Issue 1 – Article 2 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

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Open Access- Title

Correlation of Histological type, Grade and Results of IHC and SISH regarding Cerb2-HER2/neu Amplification
Author

Ioannis Manolis, Georgia Kafiri, Chryssoula Glava, Efthymios Koniaris, Maria Venetikou, Nikolaos Thalassinos, Fragkiski Anthouli-Anagnostopoulou

Pathological Anatomy Laboratory, Hippokration General Hospital, Athens, Greece
Department of Biomedical Sciences, Faculty of Health and Caring Sciences, University of West Attica (UniWA), Attica, Greece
Citation
I. Manolis, G. Kafiri, Chr Glava, E, Koniaris, M. Venetikou, N. Thalassinos, F. Anthouli-Anagnostopoulou. Correlation of Histological type, Grade and Results of IHC and SISH regarding Cerb2-HER2/neu Amplification. Review Clin. Pharmacol. Pharmacokinet. 2023, 37, 1, 11-31.
DOI: 10.5281/zenodo.10041726
Publication Date
Republication Date
02-02-2023
25-10- 2023
Full Text Language

English

Open access article

DOI: 10.5281/zenodo.10041726
Keywords
breast cancer, histological types, special histological types, HER2 amplification, IHC, SISH, Ki-67, estrogen receptors, progesterone receptors
Other Terms

Research Article
Summary
 Breast cancer is one of the most common causes of death worldwide. The increasing incidence of breast cancer and its associated mortality highlights the need for new diagnostic procedures and immunohistochemical techniques improving the therapeutic management, especially the targeted treatment. To highlight and assess the expression of oncogene HER2, regarding to the results of Immunohistochemistry (IHC) scoring 2+ and Silver DNA in Situ Hybridization (SISH) technique and identify breast cancer type, special histological types, grade, and the correlation regarding to histological type, grade, and other biomarkers such as estrogen and progesterone receptors, and Ki-67.
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