|
Open Access-Title
|
Dietary supplements: Innocent or potentially carcinogenic? |
|
|
Author
|
E. Roumelioti, P. Karkalousos, M. Trapali Laboratory of Chemistry, Biochemistry, Cosmetic Science, Department of Medical Laboratories, University of West Attica, Aigaleo, Greece |
|
|
Citation
|
E. Roumelioti, P. Karkalousos, M. Trapali.Dietary supplements: Innocent or potentially carcinogenic? Review Clin. Pharmacol. Pharmacokinet. 2022, 36,1, 05-10.
|
|
|
Publication Date
Republication Date
|
03-05-2022
17-10-2023
|
|
|
Full Text Language
|
Αγγλικά – English |
|
|
Keywords
|
dietary supplements, cancer, β-carotene, folic acid, PUFA
|
|
|
Other Terms
|
Mini-Review Article |
|
|
Summary
|
Consumption of dietary supplements has increased in recent decades. Below, it is analyzed the conditions under which the dietary supplements and their ingredients have been associated with a possible increase in cancer risk and poor prognosis of the disease. The need for careful use of supplements and their safe administration, with a view to ensuring health by recognizing potential risks, is the ultimate goal of this work. | |
| References | 1. Alsharairi, N. A., 2019. The Effects of Dietary Supplements on Asthma and Lung Cancer Risk in Smokers and Non-Smokers: A Review of the Literature. Nutrients, p. 725. 2. Al-Subeihi, A. et al., 2011. Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat. Toxicology in Vitro: Volume 25, Issue 1, February, pp. 267-285. 3. Ambrosone, C. B. et al., 2019. Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221). Journal of Clinical Oncology, 19 December, p. 804–814. 4. Baggott, J. E., Oster, R. A. & Tamura, T., 2012. Meta-analysis of cancer risk in folic acid supplementation trials. Cancer Epidemiology, February, pp. 78-81. 5. Bara Jr, T. et al., 2017. A systematic review of the possible carcinogenic role of the aristolochic acid. Romanian Journal of Morphology & Embryology, p. 41–44. 6. Binns, C., Lee, M. K. & Lee, A., 2017. Problems and Prospects: Public Health Regulation of Dietary. Annual Reviews, 22 December, p. 403–420. 7. Bjelakovic, G. et al., 2013. Is folic acid supplementation to food benefit or risk for human health?. Pteridines: Volume 24 Issue 3-4, 5 5 October. 8. Bohn, T. et al., 2019. β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion. Nutrition Society, 12 February, pp. 68-87. 9. Brasky, T. M., White, E. & Chen, C.-L., 2017. Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. Journal of Clinical Oncology, 20 October, p. 3440–3448. 10. Brasky, T. et al., 2013. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. JNCI: Journal of the National Cancer Institute, Volume 105, 10 July, p. 1132–1141. 11. Chen, C.-H.et al., 2012. Aristolochic acid-associated urothelial cancer in Taiwan. Proceedings of the National Academy of Sciences of the United States of America, 22 May, pp. 1-6. 12. Dang, H. & Quirino, J. P., 2021. Analytical Separation of Carcinogenic and Genotoxic Alkenylbenzenes in Foods and Related Products (2010–2020). Toxins, 28 May, pp. 1-25. 13. Dietz, B. & Bolton, J. L., 2007. Botanical Dietary Supplements Gone Bad. Chem Res Toxicology, April, p. 586–590. 14. Doerge, D. R., 2011. Bioavailability of soy isoflavones through placental/lactational transfer and soy food. Toxicology and Applied Pharmacology: Volume 254, Issue 2, 15 July, pp. 145-147. 15. Druesne-Pecollo, N. et al., 2010. Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. International Journal of Cancer, 21 April, pp. 172-184. 16. Eisenreich, A. et al., 2021. Alkenylbenzenes in Foods: Aspects Impeding the Evaluation of Adverse Health Effects. Foods, 10 September. 17. Fanidi, A. et al., 2018. Is high vitamin B12 status a cause of lung cancer?. International Journal of Cancer, 29 November, pp. 1499-1503. 18. Figueiredo, J. C. et al., 2009. Folic Acid and Risk of Prostate Cancer: Results From a Randomized Clinical Trial. JNCI: Journal of the National Cancer Institute: Volume 101, Issue 6, 18 March, p. 432–435. 19. Figueiredo, J. C. et al., 2010. Folic acid and prevention of colorectal adenomas: a combined analysis of randomized clinical trials. International Journal of Cancer, 17 December, pp. 192-203. 20. Furlow, B., 2017. Green Tea and Cancer. Cancer Therapy Advisor, 26 May. 21. Gonen, N. & Assaraf, Y. G., 2012. Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance. Drug Resistance Updates: Volume 15, August, pp. 183-210. 22. Hanson, S. et al., 2020. Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials. British Journal of Cancer: volume 122, 29 February, pp. 1260-1270. 23. Hsieh, C. J. et al., 2019. Cancer Hazard Identification Integrating Human Variability: The Case of Coumarin. International Journal of Toxicology, December, pp. 501-552. 24. Iwata, N. et al., 2016. The Relation between Hepatotoxicity and the Total Coumarin Intake from Traditional Japanese Medicines Containing Cinnamon Bark. Frontiers in Pharmacology, 20 June. 25. Jadot, I., Declèves, A.-E., Nortier, J. & Caron, N., 2017. An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature. Inteρnational Journal of Molecular Sciences, 29 January. 26. Jeon, Y.-J.et al., 2011. Effects of beta-carotene supplements on cancer prevention: meta-analysis of randomized controlled trials. Nutrition and Cancer, 7 October, pp. 1196-1207. 27. Jia, L. & Liu, F.-T., 2013. Why bortezomib cannot go with ‘green’?. Cancer Biolοgy & Medicine, 10 December, pp. 206-213. 28. Khan, S. A. et al., 2012. Soy isoflavone supplementation for breast cancer risk reduction: a randomized phase II trial. Cancer Prevention Research, 5 February, pp. 309-319. 29. Kim, Y.-I., 2005. Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. The Journal of Nutrition Q Volume 135, Issue 11, November, p. 2703–2709. 30. Kim, Y.-I., 2007. Folic acid fortification and supplementation–good for some but not so good for others. Nutrition Science, November, pp. 504-511. 31. Klein, E. A. et al., 2011. Vitamin E and the Risk of Prostate Cancer: Updated Results of The Selenium and Vitamin E Cancer Prevention Trial (SELECT). National Institute of Health, 12 October, p. 1549–1556. 32. Kopp, T., Abdel-Tawab, M. & Mizaikoff , B., 2020. Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review. Toxins, 13 May. 33. Kristal, A. R. et al., 2014. Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. JNCI: Journal of the National Cancer Institute, 22 February. 34. Lin, J. et al., 2009. Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial. JNCI: Journal of the National Cancer Institute, 7 January, pp. 14-23. 35. Li, X.-L.et al., 2020. Aristolochic Acid-Induced Genotoxicity and Toxicogenomic Changes in Rodents. World J Tradit Chin Med, pp. 12-25. 36. Mandair, D. et al., 2014. Prostate cancer and the influence of dietary factors and supplements: a systematic review. Nutrition & Metabolism, 16 June. 37. Martínez, M. E. et al., 2012. Dietary Supplements and Cancer Prevention: Balancing Potential Benefits Against Proven Harms. Journal of the National Cancer Institute, 25 April, pp. 732-739. 38. Messina, M., 2016. Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature. Nutrients, 24 November, pp. 1-42. 39. Miyazaki, J. & Nishiyama, H., 2017. Epidemiology of urothelial carcinoma. International Journal of urology, 24 October, pp. 730-734. 40. Moreira, R., Pereira, D. M., Valentão, P. & Andrade, P. B., 2018. Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety. International Jornal of Molecular Sciences, 5 June. 41. Neuman, M. G. et al., 2015. Hepatotoxicity of Pyrrolizidine Alkaloids. Journal of Pharmacy and Pharmaceutical Sciences, 26 November, pp. 825-843. 42. Ng, A. et al., 2017. Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. Science Translation Medicine, 18 October. 43. Pabich, M. & Materska, . M., 2019. Biological Effect of Soy Isoflavones in the Prevention of Civilization Diseases. Nutrients, July, pp. 1-13. 44. Prinsloo, G., Steffens, F., Vervoort , . J. & Rietjens, I., 2019. Risk assessment of herbal supplements containing ingredients that are genotoxic and carcinogenic. Critical Reviews in Toxicology, Volume 49, 19 December, pp. 567-579. 45. Punt, A. et al., 2009. Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats. Toxicological Sciences, August, pp. 248-259. 46. Rock, C. L. et al., 2012. Nutrition and physical activity guidelines for cancer survivors. CA: A Cancer Journals for Clinicians, 4 March, pp. 243-274. 47. Smith, D., Kim, Y.-I. & Refsum, H., 2008. Is folic acid good for everyone?. The American Journal of Clinical Nutrition, 1 March, pp. 517-533. 48. Thomas, F. et al., 2011. Green Tea Extract (Epigallocatechin-3-Gallate) Reduces Efficacy of Radiotherapy on Prostate Cancer Cells. Urology, 14 June. 49. Touillaud, M. et al., 2019. Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study. The American Journal of Clinical Nutrition, 4 March, pp. 597-605. 50. van den Berg, S. et al., 2011. Levels of Genotoxic and Carcinogenic Compounds in Plant Food Supplements and Associated Risk Assesment. Scientific Research, November, pp. 989-1010. 51. Venkateswaran, V. & Klotz, L., 2010. Diet and prostate cancer: mechanisms of action and implications for chemoprevention. Nature Reviews Urology volume 7, 20 July, pp. 442-453. 52. Wiedenfeld, H., 2011. Toxicity of Pyrrolizidine Alkaloids – a Serious Health Problem. Journal of Marmara University Institute of Health Sciences Volume: 1, 2 November, pp. 79-87. 53. Wien, T. N. et al., 2012. Cancer risk with folic acid supplements: a systematic review and metaanalysis. BMJ OPEN, 12 January, pp. 1-13. 54. Wolf, C. et al., 2021. nteractions in cancer treatment considering cancer therapy, concomitant medications, food, herbal medicine and other supplements. Journal of Cancer Research and Clinical Oncology, 17 April. 55. Xiao, C. W., 2008. Health Effects of Soy Protein and Isoflavones in Humans. The Journal of Nutrition: Volume 138, June, p. 1244–1249. |
|
|
Relative Papers
|
||
pISSN 1011-6583 • eISSN 2945-1922