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Open Access-Title
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Periostin and cancer |
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Author
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Aikaterini Kreatsoula, Maria Trapali Medical Laboratory Technologist, Athens, Hellas Athens, Hellas |
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Citation
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A. Kreatsoula, M. Trapali. Periostin and cancer. Review Clin. Pharmacol. Pharmacokinet. 2021, 35, 1, 5-14 |
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Publication Date
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02-03-2021
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Full Text Language
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Αγγλικά – English |
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Keywords
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periostin, cancer, mesenchymal proteins, treatment
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Other Terms
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Μελέτη |
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Περίληψη – Summary
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Periostin belongs to the family of mesenchymal proteins. Mesenchymal proteins are a family of non-structural proteins of the extracellular matrix that regulate a variety of biological processes in physiological and pathological conditions. Many components of this family such as periostin (POSTN), osteopontin (SPP1) have been shown to regulate in various stages of carcinogenesis, such as proliferation, invasion, remodeling of the extracellular matrix, and spread to pre-metastatic sites in distant organs. Mesenchymal proteins can be produced by cancer cells themselves or by tumor-related cells, and their synthesis can be influenced by intrinsic or exogenous tumor factors. In this paper, we will focus on the role of periostin, in the development and progression of cancer. Tumors in which their expression changes under the influence of periostin (tumors of the colon, breast, pancreas, glioma, stomach, lung, liver, leukemia and other tumors) and the usefulness of periostin as a biomarker will be analyzed. Finally, the usefulness of periostin as a therapeutic target for the cure of various cancers will be analyzed, for future directions for research and therapeutic approaches that target periostin. | |
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Relative Papers
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Online ISSN 1011-6583
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