Τόμος 34 (2020) – Τεύχος 1 –Άρθρο 3 – Review of Clinical Pharmacology and Pharmacokinetics – Διεθνής Έκδοση – Volume 34 (2020) – Issue 1 – Article 3 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

Anastasia Bothou MSc^1,2, Stefanos Zervoudis MD, PhD^1,2,3, Katerina Papakonstantinou MD, PhD², Maria Kreatsa MD, PhD², Christos Kokkonakis MD², George Tsatsaris MD¹, Aggeliki Sarella MSc², Katerina Lykeridou MD, PhD¹,Nikolaos Nikolettos MD, PhD¹, George Galazios MD, PhD¹, Panagiotis Tsikouras MD, PhD¹, George Iatrakis MD, PhD¹

¹Faculty of Medical Applied Sciences, University of West Attica, Athens, Greece

²Faculty of Medicine, University of Thrace, Alexandroupolis, Greece

³University of Montpellier-Nimes, France

This is a prospective study to assess a complementary treatment for CIN after loop electrosurgical excision procedure (LEEP). Ninety one patients were enrolled in two randomized groups: A1: LEEPalone. A2: LEEP, followed by SILOffGyn for 3 months. Pap smears repeated one year after the initial procedure showed that SILOffGyn marginally prevented CIN persistence or recurrence: 53, 3 % versus 46, 7 % (trend but non–significant difference:N.S.). Despite the N.S. difference, this complementary treatment seems to have some efficiency and could be proposed as anadditional measure to preventrecurrence after LEEP for CIN. Studies with greater number of patients and a longer period of follow-up could confirm our preliminary results.

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