Τόμος 34 (2020) – Τεύχος 3 –Άρθρο 3 – Review of Clinical Pharmacology and Pharmacokinetics – Διεθνής Έκδοση – Volume 34 (2020) – Issue 3 – Article 3 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

Fotini Mellou, Athanasia Varvaresou, Spyridon Papageorgiou, Evagelia Protopapa, Ekaterini Liatsopoulou

Laboratory of Chemistry, Biochemistry and Cosmetic Science, Division of Aesthetics and Cosmetic Science, Department of Biomedical Sciences, Faculty of Health and Caring Sciences, University of West Attica, 28 Agios Spyridonos Street, GR-12243 Egaleo, Athens, Greece

Papain is a sulphydryl, proteolytic enzyme isolated from papaya latex and is readily available from a number of sources. This enzyme has been widely used in pharmaceutical, cosmetic and nutrition area.

It is used in topical formulations as a debriding agent for the healing of open, extensive wounds and burnings. It is also employed as an enhancer for cutaneous permeation of active molecules, chemical peeling and as a progressive depilatory agent. The stability of formulations containing enzymes is a difficult parameter, thus alternatives are required to improve papain’s properties in order to allow the industry-scale manufacture of formulations in a stable manner that makes them viable for commercialization.

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