Τόμος 34 (2020) – Τεύχος 3 –Άρθρο 4 – Review of Clinical Pharmacology and Pharmacokinetics – Διεθνής Έκδοση – Volume 34 (2020) – Issue 3 – Article 4 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

By | | Πλήρες Κείμενο στα Αγγλικά - Full Text in English
Title

Correlation of Collagen type VI degeneration with cutaneous disorders
Author

Foteini Biskanaki1,2, Evaggelia Protopapa2, Aliki Liakea1, Vasilios Papadopoulos3, Eirini Thimara1, Nikolaos Kavantzas1, Andreas C. Lazaris1

1First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Building 10, Goudi, GR-11527 Athens, Greece

2Department of Biomedical Sciences. School of Health Professions. University of West, Attica, Campus 1, Athens, Greece

3Department of Histopathology, Navy Hospital of Athens, Dinokratous 70, GR-11521 Athens, Greece
Citation

F. Biskanaki, E. Protopapa, A. Liakea, V. Papadopoulos, E. Thimara, N. Kavantzas, A. C. Lazaris. Correlation of Collagen type VI degeneration with cutaneous disorders. Review Clin. Pharmacol. Pharmacokinet. 2020, 34, 3, 113-115
Publication Date
30-06-2020
Full Text Language

English
Keywords

collagen VI, dermis, solar radiation, microscope, cutaneous disorders
 Other Terms

Research
Summary
 Solar (UV) radiation is absorbed in the dermis and even more in the epidermis. For this reason, the solar elastosis appears on the surface and can change the structure of the skin’s collagen. In order to understand the expression of VI in the dermis, we studied its detection in healthy skin and in skins that have been characterized by skin cancerous tumors. The sample was tissue paraffin blocks (n =85). Immunohistochemistry (IHC protocol) was performed with the collagen type VI (ColVI) antibody. This technique unites the branches of immunology, histology, and chemistry, as it is a combination of immune and chemical reactions, which are made visible under a microscope. A total of 170 slides were studied under the microscope for safe conclusions. A statistical analysis of histological findings from healthy and pathological tissues was performed on the expression of ColVI along the dermis and in each part of the body. Collagen type VI caused degeneration in the tumor areas, whereas it was homogenous with a more intense expression along the dermis. Nevertheless, it is still a promising open field of research.
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