Τόμος 31 (2017) – Τεύχος 2 –Άρθρο 4 – Review of Clinical Pharmacology and Pharmacokinetics – Διεθνής Έκδοση – Volume 31 (2017) – Issue 2 – Article 4 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

Τίτλος – Title	Systemic Role of 25-hydroxycalciferol (25(OH) D3) – Vitamin D
Συγγραφέας – Author	Zissimopoulos Athanasios¹, Balomenos Vasilis2, Bonelis Constantinos², Georgiadi Kiriaki2, Pavlidis Pavlos³, Karakasi Valeria³, Pistola Anastasia¹, Tsigalou Christina⁴, Aristotelidou Vasilia⁵, Strataki Aphroditi¹, Lambropoulou Maria⁶ ¹Nuclear Medicine Dept ²School of Medicine ³Lab. of Forensic Sciences ⁴ School of Medicine Democritus University of Thrace Alexandroupolis, Medical Biopathology Lab.University General Hospital of Alexandroupolis, Greece ⁵School of Molecular Biology and Genetics ⁶Lab. of Histology-Embryology
Παραπομπή – Citation	Zissimopoulos A., Balomenos V., Bonelis C., Georgiadi K., Pavlidis P., Karakasi V., Pistola A., Tsigalou C., Aristotelidou V., Strataki A., Lambropoulou M. Systemic Role of 25-hydroxycalciferol (25(OH) D3) – Vitamin D. Review Clin. Pharmacol. Pharmacokinet. 2017, 31, 2, 109-111
Ημερομηνία Δημοσιευσης – Publication Date	2017
Γλώσσα Πλήρους Κειμένου – Full Text Language	Αγγλικά – English
Λέξεις κλειδιά – Keywords
Λοιποί Όροι – Other Terms	Research
Περίληψη – Summary	Vitamin D is a fat-soluble chemical substance that plays a significant role in many systems of human body. More specifically, contributes in regulation of calcium and phosphate ions homeostasis in human’s bloodstream in cooperation with Parathormone ( PTH ). The significant role of vitamin D relies on the regulation of calcium and phosphate ions concentration in bloodstream. Vitamin D promotes the absorption of calcium, magnesium, iron, phosphate ions and zinc by intestine. In this study we describe the structure, the synthesis and the role of vitamin D in many systems of human body.
Αναφορές – References	1. Linda S. Costanzo, Physiology 5th edition, Phil- adelphia, Elsevier, 2014 2. Zhang R , Li B , Gao X, Tian R, Pan Y, Jiang Y, Gu H, Wang Y, Wang Y, Liu G, Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies, The American journal of clinical nutrition, 2017 Mar. 1, doi: 10.3945/ajcn.116.140392. 3. Banerjee A, Khemka VK, Roy D, Poddar J, Roy TK, Karnam SA, Role of serum Adiponectin and Vitamin D in prediabetes and Diabetes Mellitus, Canadian Journal of Diabetes, 2017 Feb. 21, doi: 10.1016/j.jcjd.2016.10.006 4. Daniel D. Bikle, Vitamin D Metabolism, Mecha- nism of Action and Clinical Applications, Chemistry and Biology, 2014 Mar.20; 21(3): 319-329, doi: 10.1016/j.chembiol.2013.12.016 5. Pei-zhan Chen, Mian Li, Xiao-hua Duan, Jing- ying Jia, Jing-quan Li, Rui-ai Chu, Chen Yu, Jun-hua Han, Hui Wang, Pharmakokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally ad- ministered high dose of vitamin D3, Acta Pharmacol Sin, 2016 Nov; v.37(11) : 1509-1515, doi: 10.1038/aps.2016.82 6. Bendik I, Friedel A, Ross FF, Weber P, Eqqersdorfer M, Vitamin D: a critical and essential micronu- trient for human health, Frontiers in Physiology, 2014 Jul. 11;5:248, doi: 10.3389/fphys.2014.00248 7. Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Manson JE, Mayne ST, Ross AC, Shapses SA, Taylor CL, IOM committee members respond to Endocrine Society vitamin D guideline, The Journal of clinical endocrinology and metabolism, 2012 April;97(4): 1146-52, doi: 10.1210/jc.2011-2218 8. Okazaki R, Frontiers in vitamin D; basic research and clinical application. Vitamin D deficiency, insufficiency and sufficiency, 2011 Nov;21(11):9-16, doi: CliCa111115931600
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