Τόμος 31 (2017) – Τεύχος 3 –Άρθρο 4 – Review of Clinical Pharmacology and Pharmacokinetics – Διεθνής Έκδοση – Volume 31 (2017) – Issue 3 – Article 4 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

By | | Πλήρες Κείμενο στα Αγγλικά - Full Text in English
Τίτλος – Title

Kinetics of Technetium 99m-hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc99m– MIBI) as myocardial perfusion imaging agent
Συγγραφέας – Author

Zissimopoulos Athanasios1, Kermpatsou Despoina2, Bunti Sophia1, Aristotelidou Vasilia2, Pavlidis Pavlos3, Tsigalou Christina4, Karakasi Valeria3, Tsartsarakis Antonios1, Pagonopoulou Olga5, Lambropoulou Maria6

1 Nuclear Medicine Dept.,

2 School of Molecular Biology and Genetics,

3 Lab. of Forensic Sciences,

5 Lab. of Physiology,

6 Lab. of Histology-Embryology,

4 School of Medicine Democritus University of Thrace Alexandroupolis, Medical Biopathology Lab.University General Hospital of Alexandroupolis, Greece
Παραπομπή – Citation

Zissimopoulos A., Kermpatsou D., Bunti S., Aristotelidou V., Pavlidis P., Tsigalou C., Karakasi V., Tsartsarakis A., Pagonopoulou O., Lambropoulou M.. Kinetics of Technetium 99m-hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc99m– MIBI) as myocardial perfusion imaging agent. Review Clin. Pharmacol. Pharmacokinet. 2017, 31, 3, 151-155
Ημερομηνία Δημοσιευσης – Publication Date
2017
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Αγγλικά – English
Λέξεις κλειδιά – Keywords

Λοιποί Όροι – Other Terms

Μελέτη
Analysis
Περίληψη – Summary

Cardiovascular disease is one of the leading causes of death in the US, being held responsible for roughly one third of all deaths. Atherosclerotic plaques are usually present. Clinically, it is crucial to be able to evaluate the amount of damage in the heart of patients who suffer from heart  diseases. Myocardial imaging was performed using 99mTc, conjugated with an isonitrilic cationic complex. 99mTc-MIBI has shown the most favorable results. In this study we describe the kinetics of Tc-99m-labelled hexakis-methoxy-isobutyl Isonitrile for myocardial imaging.
Αναφορές – References
  1. Benjamin, E., Blaha, M., Chiuve, S., Cushman, M., Das, S., Deo, R., de Ferranti, S., Floyd, J., Fornage, M., Gillespie, C., Isasi, C., Jiménez, M., Jordan, L., Judd, S., Lackland, D., Lichtman, J., Lisabeth, L., Liu, S., Longenecker, C., Mackey, R., Matsushita, K., Mozaffarian, D., Mussolino, M., Nasir, K., Neumar, R., Palaniappan, L., Pandey, D., Thiagarajan, R., Reeves, M., Ritchey, M., Rodriguez, C., Roth, G., Rosamond, W., Sasson, C., Towfighi, A., Tsao, C., Turner, M., Virani, S., Voeks, J., Willey, J., Wilkins, J., Wu, J., Alger, H., Wong, S. and Muntner, P. (2017). Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association. Circulation, 135(10), pp.e146-e603.
  2. Sakakura, K., Nakano, M., Otsuka, F., Ladich, E., Kolodgie, F. and Virmani, R. (2013). Pathophysiology of Atherosclerosis Plaque Progression.Heart, Lung and Circulation, 22(6), pp.399-411.
  3. Nakashima, Y., Fujii, H., Sumiyoshi, S., Wight, T. and Sueishi, K. (2007). Early Human Atherosclerosis: Accumulation of Lipid and Proteoglycans in Intimal Thickenings Followed by Macrophage Infiltration. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(5), pp.1159-1165.
  4. Holman, B., Jones, A. and Lister – James, J. (1984). new Tc-99m-labeled myocardial imaging agent hexakis (t-butyisonitrile)-technetium (I) [Tc-99m TBI]: Initial experience in the human. Journal of Nucearl Medicine, 25, pp.1350-1355.
  5. Sinusas, A., Beller, G. and Watson, D. (1990). Cardiac imaging with technetium 99m-labeled isonitriles. Journal of Thoracic Imaging, 5(3), pp.20-30.
  6. Fukumoto, M. (2004). Single-photon agents for tumor imaging:201TI,99mTc-MIBI, and99mTc-tetrofosmin. Annals of Nuclear Medicine, 18(2), pp.79-95.
  7. Amin, M. (2013). P-glycoprotein Inhibition for Optimal Drug Delivery. Drug Target Insights, p.27.
  8. Arbab, A., Koizumi, K., Toyama, K., Arai, T. and Araki, T. (1999). Effects of ion channel modulators in the influx and efflux of Tc-99m-MIBI. Annals of Nuclear Medicine, 13(1), pp.27-32.
  9. Beller, G. and Watson, D. (1991). Physiological basis of myocardial perfusion imaging with the technetium 99m agents. Seminars in Nuclear Medicine, 21(3), pp.173-181.
  10. Zolle, I. (2007). Technetium-99m pharmaceuticals. 1st ed. Berlin: Springer.
  11. Piwnica-Worms, D., Kronauge, J. and Chiu, M. (1990). Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium(I) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence. Circulation, 82(5), pp.1826-1838.
  12. Backus, M., Piwnica – Worms, D., Hockett, D., Kronauge, J., Lieberman, M. and Ingram, P. et al., (1993). Microprobe analysis of Tc- MIBI in heart cells: calculation of mitochondrial membrane potential. American Journal of Physiology, 265, pp.178-187.
  13. KIT FOR THE PREPARATION OF TECHNETIUM Tc 99m SESTAMIBI INJECTION, AO92I3, R10/2015, Mallinckrodt Nuclear Medicine LLC
  14. Okada, R., Glover, D., Gaffney, T. and Williams, S. (1988). Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl- isonitrile. Circulation, 77(2), pp.491-498.
  15. Gibbons, R., Verani, M., Behrenbeck, T., Pellikka, P., O’Connor, M., Mahmarian, J., Chesebro, J. and Wackers, F. (1989). Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl- isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation, 80(5), pp.1277-1286.
  16. Wackers, F., Gibbons, R., Verani, M., Kayden, D., Pellikka, P., Behrenbeck, T., Mahmarian, J. and Zaret, B. (1989). Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal of the American College of Cardiology, 14(4), pp.861-873.
  17. Maria Santoro, G., Bisi, G., Sciagrà, R., Leoncini, M., Filippo Fazzini, P. and Meldolesi, U. (1990). Single photon emission computed tomography with technetium-99m hexakis 2-methoxyisobutyl isonitrile in acute myocardial infarction before and after thrombolytic treatment: Assessment of salvaged myocardium and prediction of late functional recovery. Journal of the American College of Cardiology, 15(2), pp.301-314.
  18. Disdarevic, S., Aplin, M., Ryan, N., Holt, S., Goldberg, L., Miles, K. and Peters, A. (2012). Renal and hepatic kinetics of Tc-99m-labelled hexakis-methoxy-isobutyl Isonitrile. Drug Metabolism Letters, 6(4), pp.242-246.
  19. Cona, M., Feng, Y., Li, Y., Chen, F., Vunckx, K., Zhou, L., Van Slambrouck, K., Rezaei, A., Gheysens, O., Nuyts, J., Verbruggen, A., Oyen, R. and Ni, Y. (2013). Comparative Study of Iodine-123-Labeled Hypericin and 99mTc-Labeled Hexakis [2-Methoxy Isobutyl Isonitrile] in a Rabbit Model of Myocardial Infarction. Journal of Cardiovascular Pharmacology, 62, pp.304-311.
  20. Uthamalingam, S., Sidhu, M., Gurm, G., Yasuda, T., Francis, S., Scott, J. and Gregory, S. (2012). Male breast uptake of 99m-Tc sestamibi in myocardial perfusion imaging. International Journal of Cardiology, 155(2), pp.e22-e23.
  21. Liu, Z. (2001). Detection of myocardial viability in ischemic-reperfused rat hearts by Tc-99m sestamibi kinetics. Journal of Nuclear Cardiology, 8(6), pp.677-686.
  22. Matsuo, S., Nakae, I., Tsutamoto, T., Okamoto, N. and Horie, M. (2007). A novel clinical indicator using Tc-99m sestamibi for evaluating cardiac mitochondrial function in patients with cardiomyopathies. Journal of Nuclear Cardiology, 14(2), pp.215-220.
  23. Fukushima, K., Momose, M., Kondo, C., Higuchi, T., Kusakabe, K. and Hagiwara, N. (2010). Myocardial 99mTc-sestamibi extraction and washout in hypertensive heart failure using an isolated rat heart. Nuclear Medicine and Biology, 37(8), pp.1005-1012.
  24. Beanlands, R., Dawood, F., Wen, W., McLaughlin, P., Butani, J. and D’Amati, G. et al., (1990). Are the kinetics of technetium-99 m methoxyisobutylisonitrile affected by cell metabolism and viability?. Circulation, 82, pp.1802-1814.
  25. Tsujimoto, Y. and Shimizu, S. (2006). Role of the mitochondrial membrane permeability transition in cell death. Apoptosis, 12(5), pp.835-840.
  26. Unno, K., Isobe, S., Izawa, H., Cheng, X., Kobayashi, M., Hirashiki, A., Yamada, T., Harada, K., Ohshima, S., Noda, A., Nagata, K., Kato, K., Yokota, M. and Murohara, T. (2009). Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy. European Heart Journal, 30(15), pp.1853-1862.
  27. Fukushima, K., Momose, M., Kondo, C., Kusakabe, K. and Kasanuki, H. (2007). Myocardial kinetics of 201Thallium, 99mTc-tetrofosmin, and 99mTc-sestamibi in an acute ischemia–reperfusion model using isolated rat heart. Annals of Nuclear Medicine, 21(5), pp.267-273.
  28. Masuda, A., Yoshinaga, K., Naya, M., Manabe, O., Yamada, S., Iwano, H., Okada, T., Katoh, C., Takeishi, Y., Tsutsui, H. and Tamaki, N. (2016). Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome. EJNMMI Research, 6(41).
  29. Hotchkiss, R., Strasser, A., McDunn, J. and Swanson, P. (2009). Cell Death. New England Journal of Medicine, 361(16), pp.1570-1583.
  30. Takeishi, Y., Sukekawa, H., Fujiwara, S., Ikeno, E., Sasaki, Y. and Tomoike, H. (1996). Reverse redistribution of technetium-99m-sestamibi following direct PTCA in acute myocardial infarction. Journal of Nuclear Medicine, 37(8), pp.1289-1294.
  31. Hayashi, D., Ohshima, S., Isobe, S., Cheng, X., Unno, K., Funahashi, H., Shinoda, N., Okumura, T., Hirashiki, A., Kato, K. and Murohara, T. (2013). Increased 99mTc-Sestamibi Washout Reflects Impaired Myocardial Contractile and Relaxation Reserve During Dobutamine Stress Due to Mitochondrial Dysfunction in Dilated Cardiomyopathy Patients. Journal of the American College of Cardiology, 61(19), pp.2007-2017.
  32. Wu, I., Ohsawa, I., Fuku, N. and Tanaka, M. (2010). Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function. Annals of the New York Academy of Sciences, 1201(1), pp.111-120.
  33. Parathyroid adenoma detected with 99mTc-tetrofosmin dual-phase scintigraphy: A case report(Article) Romanidis, K.aKarathanos, E.b Nagorni, E.-A.aGiatromanolaki, A.c Sibridis, E.c Zissimopoulos, A.b Vogiatzaki, T.d Simopoulos, C.a, Pitiakoudis, M.a BMC Research NotesOpen Access Volume 7, Issue 1, 4 June 2014, Article number 335
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