Open Access Original Article
Intranipple injection with methylene blue for tracing axillary sentinel lymph nodes in rats: A preliminary feasibility study
Fengjiang Qu1,*, Di Wu2,*, Zhimin Fan2,*, Chenyang Hu2,*, Jinxiu Ma2,*,Stefanos Zervoudis3,4,5, Xiaozhen Wang2,*
1 Department of Emergency Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, Jilin Province, China Department of Breast Surgery
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Published: 28 December 2023; https://doi.org/10.61873/MVVA6586
Abstract
Background and purpose: Investigate the feasibility of intranipple injection (INN) of methylene blue dye (MB) for tracing the axillary sentinel lymph node (SLN) in rats, to provide different injection methods for finding SLN injection tracers and offer an experimental basis for specific localization of SLN.
Conclusion: Tracer detection of SLNs by INN injection in rats is feasible, and the detection rate of SLNs by INN is the same as that of IAA; there is no significant difference in the median number of detected SLNs between the two injection methods. No nipple necrosis was observed after INN with MB.
Keywords: Intranipple injection, sentinel lymph node biopsy
Citation
Please cite as:
F. Qu, D. Wu, Z. Fan, C. Hu, J. Ma, S. Zervoudis, X. Wang. Intranipple injection with methylene blue for tracing axillary sentinel lymph nodes in rats: A preliminary feasibility study. Rev. Clin. Pharmacol. Pharmacokinet. Int. Ed., 2023, 37, 3, 123-128. https://doi.org/10.61873/MVVA6586