Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Supplementary Issue 1

Open Access Review Paper

In vitro skin models. Challenges and Future Steps

Sophia Letsiou¹, Apostolos Beloukas¹, Efstathios Rallis¹, Vasiliki Kefala¹¹Department of Biomedical Sciences, School of Health Sciences and Welfare, University of West Attica, Ag. Spyridonos Str., Egaleo 12243, Athens, Greece

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Published: 17 February 2024; https://doi.org/10.61873/FCXV3865

Abstract
The in vitro models have great potential in skin-related research as well as in testing for active ingredients in cosmetics, dermocosmetics and pharmaceuticals. Human skin behavior can be simulated in vitro using a variety of methods ranging from cell monolayer models to complicated organotypic and bioengineered three-dimensional models. Moreover, skin in vitro models offer an excellent alternative to animal testing in cosmetics and some of them are validated to be used as preclinical as-says. However, the in vitro simulation of the whole skin together with its appendages is still in its early stages. In this article we discuss a short evolution of skin models with its challenges and its future.

Keywords: in vitro models, skin models, three-dimensional models, cosmetics

Please cite as:
Letsiou S., Beloukas A., Rallis E., Kefala V. In vitro skin models. Challenges and Future Steps. Rev. Clin. Pharmacol. Pharmacokinet. Int. Ed. 38(Sup1):63-65 (2024). https://doi.org/10.61873/FCXV3865