Review of Clinical Pharmacology and Pharmacokinetics – International Edition – Volume 38 (2024) – Issue 1

Lower extremity peripheral vascular disease is a typical, rapidly progressive, and disabling condition. In most patients,limb ischemia is detected at late stages of the disease. As a result, they are at high risk of limb loss, which makes acomplete conventional treatment ineffective. In this situation, balloon angioplasty and stenting of lower extremity ar-teries are considered the optimal modern method of treating patients with critical limb ischemia. This study aims toevaluate the effectiveness of endovascular techniques to improve revascularization during the treatment of criticallower extremity ischemia. The research involved a comprehensive examination and endovascular treatment of 170patients with occlusive-stenotic lesions of the lower extremity arteries. The patients were operated for critical ischemiabetween January 2016 and December 2022, and the effectiveness of the measures taken was analyzed. It was foundthat the pathology under the study requires timely diagnosis and identification of the severity of limb ischemia andcirculatory disorders, with the subsequent preparation of an appropriate treatment plan. The author discussed themain problems accompanying balloon angioplasty and stenting of the lower extremity arteries in patients with criticallimb ischemia. Also, the experience of developed countries in the optimization and improvement of the studied tech-nique was studied. It has been proven that the diagnosis of lower extremity vascular disease is related to specificdifficulties. However, it can be made on an outpatient basis by analyzing medical examination data and simple labor-atory methods.

Keywords: endovascular treatment, angioplasty, stent, occlusive-stenotic lesions, critical lower extremity ischemia, endovascular devices