Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

Open Access Research

Cytotoxic effects of the Crassula ovata n-hexane fraction on human esophagus cancer KYSE-30 cells
Hawraa Kareem Al-yassery¹

, Enas Jawad Kadhim²

¹Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Babylon, Babylon, Iraq
²Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Baghdad, Baghdad, Iraq

*Corresponding author: Enas Jawad Kadhim, Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Baghdad, Baghdad, Iraq; Tel.: +964-(0)7809052154
E-mail: ienas.fahd@copharm.uobaghdad.edu.iq

Download PDF

Published: 5 May 2024; https://doi.org/10.61873/JMOB1139

Abstract
The current study shows the cytotoxicity effect of the Crassula ovata n-hexane extract on esophagus cancer. C. ovata is a perennial succulent plant belonging to the Crassulaceae family. In Africa, the leaves were used medicinally to cure epilepsy and diarrhoea by boiling them in milk. The hexane fraction, which is obtained through the maceration method, demonstrates the presence of many compounds that have an anticancer effect, which are obtained by gas chromatography – mass spectroscopy. The phytosterol compound was isolated by a preparative thin layer chromatograph and was identified by liquid chromatography – mass spectroscopy. The hexane fraction was found to possess a strong anticancer effect against esophagus cancer. The obtained data from the human esophagus cancer KYSE-30 cell-line were analysed by one-way ANOVA, with a significance level of p<0.05.

Keywords: b-sitosterol, Crassula ovata, cytotoxicity, esophagus cancer, phytosterol

Please cite as:
Al-yassery H.K, Kadhim E.J. Cytotoxic effects of the Crassula ovata n-hexane fraction on human esophagus cancer KYSE-30 cells. Rev. Clin. Pharmacol. Pharmacokinet. Int. Ed. 38(Sup2): 97-100 (2024).
https://doi.org/10.61873/JMOB1139