Open Access Review
Regulatory B-cells: immunomodulating mechanisms and important cellular targets underlining immunotherapy by immunoregulation
Zaman I. L. Al-Kaabi1,*
1Department of Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Hillah, Iraq
*Corresponding author: Zaman I. L. Al-Kaabi, Department of Clinical Laboratory Sciences, College of Pharmacy, University of Babylon, Hillah, Iraq; Tel.: +964-(0)7825372592
E-mail: zaman_medicalmsc@yahoo.com
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Published: 5 May 2024; https://doi.org/10.61873/BAOW5445
Abstract
Regulatory B-cells (Breg cells) represent as an important modulator of the immune system and their role is unique in autoimmunity, infection, tolerance to transplants, allergy, and cancer. Several regulatory mechanisms exist by which Breg cells can control the function of other immune cells through two main pathways: the secretion of soluble molecules and the use of cell surface-expressed molecules. Anti-inflammatory cytokine interleukin-10 acts as the hallmark of Breg cell function; other cytokines with a similar role include the transforming growth factor-beta and interleukin-35. Breg B cells also release the cytotoxic granzyme B that mediates cell apoptosis. Cell surface-expressed proteins include FasL, CD80, CD86, CD73, CD1d, and PD-L1. The present article reviews the immunosuppressive pathways in order to understand how they emerge and are induced to evoke their regulatory activities, and how we can benefit from them in the field of immunotherapy.
Keywords: immunosuppressive mechanisms, regulatory B-cells, IL-10, TGF-β, PD-L1
Please cite as:
Al-Kaabi Z. I. L. Regulatory B-cells: immunomodulating mechanisms and important cellular targets underlining immunotherapy by immunoregulation. Rev. Clin. Pharmacol. Pharmacokinet. Int. Ed. 38 (Sup2): 185-188 (2024). https://doi.org/10.61873/BAOW5445