| Title | Inhibition of histamine-induced wheal and flare reactions by cetirizine 2HCl and mequitazine both in healthy and atopic subjects: a comparative double blind placebo controlled study | |
| Authors | John Sidiropoulos, Michael Volonakis and Kalliopi Kontou-Fili
Section of Allergy, Laikon General Hospital, Goudi |
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| Citation | Sidiropoulos, J., Volonakis, M., Kontou-Fili, K.: Inhibition of histamine-induced wheal and flare reactions by cetirizine 2HCI and mequitazine both in healthy and atopic subjects: a comparative double blind placebo controlled study, Epitheorese Klin. Farmakol. Farmakokinet. 2(2): 110-120 (1988) | |
| Publication Date | 1988-10 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Histamine, wheat, flare, injection, HCI, cetirizine, drug. | |
| Other Terms | review article | |
| Summary | The efficacy of a single oral dose of 10 mg cetirizine 2HCI in inhibiting histamine- induced wheat (W) and flare (F) reactions was evaluated and compared to placebo and 5 mg mequitazine, in a double blind crossover study involving 12 atopic and 12 healthy subjects. Two strengths of histamine (H) – 10 and 100 μg/ml – were injected in the forearm before and 2, 4 and 6 hours following the drug ingestion. The W and F area was measured by planimetry 10 minutes after histamine injection. Cetirizine 2HCI was found to be superior to placebo and mequitazine W and F reactions, induced by both concentrations of H. Furthermore cetirizine’s anti H, cutaneous effects were observed earlier, were more pronounced and lasted longer; all differences were statistically significant. These results are in accordance with other findings in healthy colunteers after use of terfenadine as comparison drug. | |
| References | 1. Rihoux, J.P., Dupont, P.: Comparative study of the peripheral and central effects of terfenadine and cetirizine 2HCl. Ann. Allergy 59: 235 (1987)
2. Pechadre, J.C., Trolese, J.F., Bloom, M., Dupont, P., Rihoux, J.P.: Compared central and peripheral effects of terfenadine and cetirizine 2HCI. Allergologia e Immunologia Clinica 2: 83 (1987) 3. Snyder, S., Snowman, A.: Receptor effects of cetirizine. Ann. Allergy 59 (6) (Part II): 4 (1987) 4. Fadel, R., Herpin-Richard, N., Rihoux, J.P., Henocq, E.: Inhibitory effect of cetirizine 2HCI on eosinophil migration in vivo. Clin. Allergy 17: 373 (1987) 5. Charlesworth, E.N., Kagey-Sobotka, A., Norman, P.S., Lightenstein, L.M.: Effects of cetirizine on mast cell mediator release and cellular traffic during the cutaneous late phase response. J. AH. CHn. Immunol. Allergy Abstracts 81: 1, 212, abstr. 176 (1988) 6. Symposium International sur I histamine: Donnies actuelles sur la Mequitazine, les mediateurs de I ‘allergie et la vigilance. Le Quotidien du Medecin, Supplement au numero 2863 du 25.1.1983 7. Uzan, A., Le Fur, G.: Inhibition de la phosphodiesterase de I ΆΜΡ-3′,5’ cyclique du poumon de cobaye par un nouvel anti-allergique la (Quinuclidinyl-3-methyl)-10-ph0nothia- zine (LM 209). Arch. Int. Pharmacodyn. ThSr. 219(1): 160 (1976) 8. Harvey, R.P., Schocket, A.L.: The effect of H, and H2 blockade on cutaneous histamine response in man. J. Allergy Clin. Immunol. 65: 1356 (1980) 9. Kontou-Fili, Κ., Paleologos, G., Herakleous, M.: Suppression of histamine-induced skin reactions by loratadine and. cetirizine 2 HCI; a comparative double blind placebo controlled study. Eur. J. Clin. Pharmacol, (in press) (1989) 10. Poppa, V.T.: Effect of an H,-blocker, chlorpheniramine, on inhalation tests with histamine and allergen in allergic asthma. Chest 78: 442 (1980) 11. Howarth, P.H., Holgate, S.T.: Astemizole, an Ht-antagonist in allergic asthma. J. Allergy Clin. Immunol. 75 (1): Part 2 (1985) 12. Tashkin, D.P., Brik, A., Gong, H. Jr.: Cetirizine inhibition of histamine-induced bronchospasm. Ann. Allergy 59 (Part II): 49 (1987) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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