Title | On the action of lucanthone and its analogue hycanthone | |
Author | Maria Pelecanou and Panayotis Catsoulacos
Laboratory of Pharmaceutical Chemistry, University of Patras, Greece |
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Citation | Pelecanou, M., Catsoulacos, P.: On the action of lucanthone and its analogue hycanthone, Epitheorese Klin. Farmakol. Farmakokinet. 3(1): 13-21 (1989) | |
Publication Date | 1989-07 | |
Full Text Language | English | |
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Keywords | Lucanthone, hycanthone, metabolism, Schistosoma mansoni, Schistosoma haematobium, DNA, carcinostatic effectiveness. | |
Other Terms | review article | |
Summary | Lucanthone, the 1 -[2- (diethyfamino) ethylamino]-4- methyl-10-thioxanthenone, was the first non-antimoniaf drug active against Schistosoma mansoni and Schistosoma haematobium. Lucanthone is not effective per se, but is metabofically converted by the host into its 4-hydroxymethyi analogue, hycanthone, which is considered the therapeutically active substance. Studies on the pharmacological properties of lucanthone and hycanthone have revealed a variety of effects on muscular activity and neurotransmitter systems of schistosomes as well as on nucleic acid and protein biosynthesis. Both drugs are capable of binding to DNA in organisms and animal cells in vitro. Lucanthone and hycanthone have also shown carcinostatic effectiveness against a variety of mouse tumors and exhibited mutagenic activity in bacterial and mammalian cell systems. Lucanthone has proven to be a potent teratogen in mice and rabbits. This article comprises the basic references on the action of lucanthone and hycanthone. | |
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