Τόμος 3 (1989) – Τεύχος 2 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 3 (1989) – Issue 2 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

1. Section of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, and Institute of Materials Science, University of Connecticut, Storrs, CT 06269

2. Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139

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2.         Bach, D., Raz, A., Goldman, R.: The effect of hashish compounds on phospholipid phase transition. Biochim. Biophys. Acta 436: 889 (1976)

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7.         Phillips, G.H.: Structure-activity relationships in steroidal anaesthetics. Steroid. Biochem. 6: 607 (1975)

8.         Makriyannis, A., Fesik, S.W.: Geometric requirements for membrane perturbation and anesthetic activity. Conformational analysis of alphaxalone and A,6-alphaxalone and 2H NMR studies on their interactions with model membranes. Mot. Pharmacol. 27: 624 (1985)

9.         Makriyannis, A., Fesik, S.: Mechanism of steroid anesthetic action: Interactions of alphaxalone and A,6-alphaxalone with bilayer vesicles. J. Med. Chem. 26: 463 (1983)

10.       Jain, M.K., Wu, N.M.: Effect of small molecules on the dipalmitoyl lecithin liposomal bilayer. III. Phase transition in lipid bilayer. J. Membrane Biol. 34: 157 (1977)

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12.       Herbette, L., Katz, A.M., Sturtevart, J.M.: Comparisons of the interaction of propranolol and timolol with model and biological membrane systems. Mol. Pharmacol. 24: 259 (1983)

13. Makriyannis, A., Fesik, S.W., Kriwacki, R.: Nuclear magnetic resonance in drug research. Some new developments. In New Methods in Drug Research (A. Makriyannis, ed.), vol. 1, p. 19, J.R. Prous, Barcelona, Spain, 1985

14.       Dufourc, E.J., Smith, I.C.P., Jarrell, H.: Interaction of amphotericin B with membrane lipids as viewed by 2H- NMR. Biochim. Biophys. Acta 778: 435 (1984)

15.       Auger, M., Jarrell, H.C., Smith, I.C.P.: Interactions of the local anesthetic tetracaine with membranes containing phosphatidylcholine and cholesterol: A 2H NMR study. Biochemistry 27: 4660 (1988)

16.       Makriyannis, A., Siminovitch, D.J., Das Gupta, S.K., Griffin, R.G.: Studies on the interaction of anaesthetic steroids with phosphatidylcholine using 2H and 13C solid state NMR. Biochim. Biophys. Acta 859: 49 (1986)

17.       Ladbrooke, B.D., Chapman, D.: Thermal analysis of lipids, proteins and biological membranes. View and summary of some recent studies. Chem. Phys. Lipids 3: 304 (1969)

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19.       McElhaney, R.N.: The use of differential scanning calorimetry and differential thermal analysis in studies of model and biological membranes. Chem. Phys. Lipids. 30 (2-3): 229 (1982)

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23.       Franks, N.P., Levine, Y.K.: Low angle x-ray diffraction. In: Membrane Spectroscopy (E. Grell, ed.), p. 437, Springer-Verlag, New York, 1981

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26.       Griffin, R.: Solid state nuclear magnetic resonance of lipid bilayers. Methods of Enzymology 72: 108 (1981)

27.       Groot, H.J.M., Copig, V., Smith, S.O., Allien, P.J., Winkel, C., Lugtenburg, J., Herzfeld, J., Griffin, R.G.: Magic-angle-sample spinning NMR difference spectroscopy. J. Magn. Res on. 77: 251 (198.8)

28.       Fyfe, C.A.: Solid State NMR for Chemists. C.F.C. Press, Ontario, Canada, 1983

29.       Davis, J.H.: The description of membrane lipid conformation, order and dynamics by 2H-NMR. Biochim. Biophys. Acta 737: 117 (1983)

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33.       Ekiel, I.H., Hughes, L., Burton, G.W., Jovall, P.A., Ingold, K.U., Smith, I.C.P.: Structure and dynamics of atocopherol in model membranes and in solution: A broad line and high-resolution NMR study. Biochemistry 27: 1432 (1988)

34.       Makriyannis, A., Banijamali, A., Jarrell, H.C., Yang, D.P.: The orientation of (—)-A9-THC in DPPC bilayers as determined from solid state 2H-NMR. Biochim. Biophys. Acta in press (1989)

35.       Harbison, G.S., Smith, S.O., Pardoen, J.A., Courtin, Lugtenburg, J., Herzfeld, J., Mathies, R.A., Griffin, R.G.: So lie state ‘3C NMR detection of a perturbed 6-s-trans chromophore in bacteriorodopsin. Biochemistry 24: 6955 (1985)

36.       Van der Schyf, C.J., Mavromoustakos, T. and Makriyan- nis, A.: The conformation of (—)8α and (—)8β-hydroxy-Δ9-tetrahydrocannabinols and their interactions with membranes. Life Sciences 42: 2231 (1988)

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38.       Makriyannis, A.: Solid state nuclear magnetic resonance spectroscopy in drug research. In: Molecular Basis of the Action of Drugs and Toxic Substrates. Proceedings International Symposium San Francisco, California, April 23-26, 1987. (T.P. Singer, N. Castagnoli, C.C. Wang, eds), Walter de Gruyter, Berlin, 1988

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