Τόμος 3 (1989) – Τεύχος 2 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 3 (1989) – Issue 2 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Department of Biochemistry, University of Surrey, Guildford, Surrey, GU2 5XH, U.K

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2.         Pelkonen, O. and Nebert, D.W.: Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenesis. Pharmacol. Rev. 34: 189 (1982)

3.         Gelboin, H.V.: Benzo(a)pyrene metabolism, activation and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes. Physiol. Rev. 60: 1107 (1980)

4.         De Pierre, J.W. and Ernster, L: The metabolism of polycyclic hydrocarbons and its relationship to cancer. Biochim. Biophys. Acta 473: 149 (1978)

5.         Buening, M.K., Wislocki, P.G., Levin, W., Yagi, H., Thak- ker, D.R., Akagi, H., Koreeda, M„ Jerina, D.M. and Conney, A.H.: Tumorigenicity of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7β,8α- dihydroxy- 9a, 10o-epoxy- 7,8,9,10 -tetrahydrobenzo(a)pyrene. Proc. Natl. Acad Sci. 75: 5358 (1978)

6.         Koreeda, M., Moore, P.D., Wislocki, P.G., Levin, W., Conney, A.H., Yagi, H. and Jerina, D.M.: Binding of benzo(a)pyrene 7,8-diol-9,10-epoxides to DNA, RNA and protein of mouse skin occurs with high stereoselectivity. Science 199: (1978)

7.         Meehan, T. and Straub, Κ.: Double-stranded DNA stereo- selectively binds benzo(a)pyrene diol epoxides. Nature 277: 410 (1979)

8.         Wood, A.W., Wislocki, P.G., Chang, R.L, Levin, W., Lu, A.Y.H., Yagi, H., Hernandez, O., Jerina, D.M. and Conney, A.H.: Mutagenicity and cytotoxicity of benzo(a) pyrene benzo-ring epoxides. Cancer Res. 36: 3358 (1976)

9.         Gonzalez, F.J.: The molecular biology of cytochrome P450s. Pharmacol. Rev. 40: 243 (1989)

10.       Ioannides, C. and Parke, D.V.: The cytochromes P-448 – A unique family of enzymes involved in chemical toxicity and chemical carcinogenesis. Biochem. Pharmacol. 36: 4197 (1987)

11.       Ioannides, C. and Parke, D.V.: The cytochrome P450 I gene family of microsomal haemoproteins and their role in the metabolic activation of chemicals. Drug Met. Rev. In press.

12.       Wood, A.W., Levin. W., Lu, A.Y.H., Yagi, H., Hernandez, O., Jerina, D.M. and Conney, A.H.: Metabolism of benzo(a)pyrene and benzo(a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes. J. Biol. Chem. 251: 4882 (1976)

13.       Deutsch, J., Leutz, J., Yang, S.K., Gelboin, H.V., Chiang, Y.L., Vatsis, K.P. and Coon, M.J.: Regio- and stereo-selectivity of various forms of purified cytochrome P-450 in the metabolism of benzo(a)pyrene and (-)-trans-7,8- dihydroxy-7,8-dihydrobenzo(a)pyrene as shown by product formation and binding to DNA. Proc. Natl. Acad. Sci. 75: 3123 (1978)

14.       Marnett, L.J., Panthananickal, A. and Reed, G.A.: Metabolic activation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene during prostaglandin biosynthesis. Drug Met. Rev. 13: 235 (1982)

15.       Krauss, R.S. and Eling, T.E.: Arachidonic acid-dependent cooxidation. A potential pathway for the activation of chemical carcinogens in vivo. Biochem. Pharmacol. 33: 3319 (1984)

16.       Phillipson, C.E. and Ioannides, C.: Metabolic activation of polycyclic aromatic hydrocarbons to mutagens in the Ames test by various animal species including man. Mut. Res. 211: 147 (1989)

17.       Ayrton, A.D., Trinick, J., Wood, B.P., Smith, J.N. and loannides, C.: Induction of the rat hepatic microsomal mixed-function oxidases by two azaarenes. A comparison with their non-heterocyclic analogues. Biochem. Pharmacol. 37: 4565 (1988)

18.       Phillipison, C.E., Godden, P.M.M., Lum, P.Y., loannides, C. and Parke, D.V.: Determination of cytochrome P-448 activity in biological tissues. Biochem. J. 221: 81 (1984)

19.       Ioannides, C., Lum, P.Y. and Parke, D.V.: Cytochrome P-448 and the activation of toxic chemicals and carcinogens. Xenobiotica 14: 119 (1984)

20.       Nebert, D.W.: Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds. Pharmac. Ther. 6: 395 (1979)

21.       Pelkonen, O., Pasanen, M., Kuha, H., Gachalyi, B., Kairaluoma, M., Sotaniemi, E.A., Park, S.S., Friedman, F.K. and Gelboin, H.V.: The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. Brit. J. Clin. Pharmacol. 22: 125 (1986)

22.       Conney, A.H.: Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes, Memorial lecture. Cancer Res. 42: 4875 (1982)

23.       Lijinsky, W. and Shubik, P.: Benzo(a)pyrene and other polynuclear hydrocarbons in charcoal-broiled meat. Science 145: 53 (1964)

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