| Title | The effect of azathioprine on postextraction bone healing in rats | |
| Authors | John Zografos, John Papadopoulos, Asterios Triantafyllou and Anna Patrikiou
Experimental Pharmacology Laboratory, Medical Department and Oral and Maxillofacial Surgery Clinic, Dental Department, University of Athens, Greece |
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| Citation | Zografos, J., Papadopoulos, J., Triantafyllou, A., Patrikiou, A.: The effect of azathioprine on postextraction bone healing in rats, Epitheorese Klin. Farmakol. Farmakokinet. 4(1): 49-53 (1990) | |
| Publication Date | Received for publication: October 15, 1989
Accepted for publication: January 5, 1990 |
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| Full Text Language | English | |
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| Keywords | Azathioprine, postextraction healing, rats. | |
| Other Terms | review article | |
| Summary | The effect of chronic use of 20 mg/kg of azathioprine on bone healing of postextraction socket was studied 35 days following tooth extraction, in young male rats. The immunosuppressive effect of the drug was assessed by the statistically significant reduction in the weight of the thymus and spleen, as well as in the number of W.B.C. Histometric study showed that the difference between the osseous tissue filling the post-extraction socket and that of the area next to socket was statistically significant, in both groups, experimental (p<0.001) and control (p<0.01). The difference noticed on the osseous tissue filling the socket of the experimental and that of the control group was not statistically significant (p>0.1). It is presumed that the chronic use of azathioprine does not delay bone healing: Moreover bone healing continues even, after the 35th postextraction day, in both groups. | |
| References | 1. Malamud, Gonzalez, E., Huaichiu, Malt, R.: Inhibition of cell proliferation by Azathioprine. Cancer Res. 32: 1226 (1972)2. Van Furth, R., Gassmann, A., Dtesselhoff den Dulk, M.: The effect of Azathioprine on the cell cycle of promonocytes and the production of monocytes in the bone marrow, J. Exp. Med 141: 531 (1975)
3. Arumugam, S., Nimmannit, S., Enquist, L: The effect of immunosupression on wound healing. Surg. Gynecol. Obstet. 133: 72 (1971) 4. Githens, J., Rosenkrantz, J., Tunnoch, S.: Teratogenic effects of azathioprine. J. Pediatr. 66: 959 (1965) 5. Spreafico, F., Donelli, M.G., Bossr, A., Vecchi, A., Standen, S., Garattini, S.: Immunodepressant activity and 6-Mer- captopurine levels after administration of 6-Mercaptopurine and Azathioprine. Transplantation 16: 269 (1973) 6. Seia, J., Jaffe, A.: The role of bone remodelling in the healing of extraction socket in rats. Acta Anat. 97: 241 (1977) 7. Sommer-Tsilenis, E., Sauer, H., Kruse, H.: Delaying effect .of cyclophosphamide on bone fracture healing. Chemical analysis of rat femora. Arch. Orthop. Traumat. Surg. 101: 89 (1983) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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