| Title | Positron emission tomography in pharmacological research: brain glucose metabolism in healthy volunteers | |
| Author | Basil A. Kokkas
Department of Nuclear Medicine, Erasme Hospital of Brussels, U.L.B. Belgium and Department of Experimental Pharmacology, Aristotelian University of Thessaloniki, Greece |
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| Citation | Kokkas, B.A.: Positron emission tomography in pharmacological research: brain glucose metabolism in healthy volunteers, Epitheorese Klin. Farmakol. Farmakokinet. 4(1): 54-58 (1990) | |
| Publication Date | Received for publication: October 20, 1989
Accepted for publication: January 29, 1990 |
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| Full Text Language | English | |
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| Keywords | Positron emission tomography, glucose metabolism. | |
| Other Terms | review article | |
| Summary | Brain glucose metabolism was studied in 7 healthy volunteers by means of positron emission tomography: (78F) fluoro-2-deoxy-D-glucose was used for the method. Total brain glucose metabolism was found to be 27.09+3.52 mM/100 g/min. Median region 29.30.23.31 of the limbic lobe presented the maximum of values (L: 39.18+4.22 and R: 38.05±3.67 mM/100 g/min), while the inferior temporal lobe (L: 20.11±2.77 and R: 20.48+3.64 mM/100 g/min), as well as the cortex of cerebelum (L: 25.5+4.43 and R: 25.64±4.63 mM/100 g/min), the minimum ones. Since PET images are truly functional representations of brain activity, behavioral or pharmacological responses can be measured in both normal individuals and patients with cerebral disorders. | |
| References | 1. Hoffman, E., Phelps, M.: Positron emission tomography: Principles and quantitation. In: Positron Emission Tomography and Autoradiography (M. Phelps, J. Mazziota, H. Schelbert, eds), p. 237, Raven Press, New York, 1986
2. Merhige, M., Garza, D.: Positron emission tomography of the heart: Mapping flow and metabolism in vivo. Mayo Clin. Proc. 64: 716 (1989) 3. Forstrom, L.: Positron emission tomography. The promise of metabolic imaging. Mayo Clin. Proc. 64: 720 (1989) 4. Graham, M., Lewellen, T.: Positron emission tomography and its role in metabolic imaging. Mayo Clin. Proc. 64: 721 (1989) 5. Mazziota, J. and Phelps, M.: Positron emission tomography studies of the brain. In: Positron Emission Tomography and Autoradiography (M. Phelps, J. Mazziota, H. Schelbert, eds), p. 493, Raven Press, New York, 1986 6. Young, A., Frey, K., Agranoff, B.: Receptor assays in vitro and in vivo. In: Positron Emission Tomography and Autoradiography (M. Phelps, J. Mazziota, H. Schelbert, eds), p. 73, Raven Press, New York, 1986. 7. Heis, W., Beil, C., Herholz, K., Pawlik, G., Wagner, R., Wiehard, K.: Atlas of Positron Emission Tomography of the Brain. Springer-Verlag, pp. 47, 1,05, Berlin, 1985 8. Reivich, M., Kuhl, D., Wolf, A.: The (18F) fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ. Res. 44: 127 (1979) 9. Sokoloff. L.: Basic principles in imaging of regional cerebral metabolic rates. In: Brain Imaging and Brain Function (L. Sokoloff, ed.), p. 21, Raven Press, New York, 1985 10. Kuhl, D.: Mapping local cerebral glucose metabolism in stroke, degenerative diseases and epilepsy; In: Functional Radionuclide Imaging of the Brain (Ph. Magistreti, ed.), p. 257, Raven Press, New York, 1983 11. Greenberg, J., Reivich, M., Alavi, A.: Metabolic mapping of functional activity in human subjects with l8FDC technique. Science 212: 678 (1981) 12. Schade, J.: Einführung in die Neurologie. Gustav Fischer Verlag, p. 61, Stuttgart, 1975 |
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Online ISSN 1011-6575
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