| Title | Dissolution and bioavailability evaluation of three brands of paracetamol tablets | |
| Author | Kortstantinos Augoustakis¹ and Ioannis Niopas²
1. Laboratory of Pharmaceutical Technology and 2. Laboratory of Pharmacology, Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece |
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| Citation | Augoustakis, K., Niopas, I.: Dissolution and bioavailability evaluation of three brands of paracetamol tablets, Epitheorese Klin. Farmakol. Farmakokinet. 5(1): 58-61 (1991) | |
| Publication Date | Received for publication: January 5, 1991
Accepted for publication: February 25, 1991 |
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| Full Text Language | English | |
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| Keywords | Paracetamol, mechanical strength, dissolution, bioavailability | |
| Other Terms | review article | |
| Summary | Three different brands of paracetamol tablets were evaluated for their mechanical strength, dissolution rate, and bioavailability. The in vivo evaluation of comparative bioavailability was studied in eight healthy volunteers using a cross-over study. The urine was collected for 24 hours and after hydrolysis of paracetamol and its conjugates the total drug was determined by the method of Welch and Conney. The relative bioavailabilities, with respect to a standard equivalent solution of 500 mg of paracetamol, were found to be statistically not significant. The dissolution rate was determined according to the method of USP XXI and the dissolution rate constants were found to be also statistically not significant. In contrast, the mechanical strength was found to differ significantly. This points out the inadequacy of mechanical strength to predict the dissolution rate of tablets. | |
| References | 1. Savides, M.C., Oehme, F.W.: J. Appl Toxicol. 3: 96 (1983)
2. Gwilt, J.R., Robertson, A., Goldman, L, Blanchard, A.W.: J. Pharm. Pharmacol. 15: 445 (1963) 3. Prescott, L.F.: Clin. Pharmacol. Ther. 10: 383 (1969) 4. McGilveray, I.J., Mattok, G.L, Fooks, J.R., Jordan, N., Cook, D.: Can. J. Pharm. Sci. 6: 38 (1971) 5. Sotiropoulos, J.B., Deutsch, T., Plakogiannis, F.M.: J. Pharm. Sci. 70: 422 (1981) 6. Welch, R.M., Conney, A.H.: Clin. Chem. 11: 1065 (1965) 7. The United States Pharmacopeia, XXI, Mack Publishing Co., Easton, Pa., 1243 (1985) 8. M. Rowland, T.N. Tozer (eds): Clinical Pharmacokinetics Concepts and Applications. 2nd Ed., Lea and Febiger, Philadelphia, 1989 9. G.G. Gibson, P. Skett (eds): Introduction to Drug Metabolism, p. 276, Chapman and Hall, London, 1986 |
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Online ISSN 1011-6575
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