Τόμος 5 (1991) – Τεύχος 2 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 5 (1991) – Issue 2 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

By | | Α. Κουγιουμτζής - A. Kouyoumtzis, Αθανάσιος Γ. Παραδέλης - Athanasios G. Paradelis, Άρθρο επισκόπησης - Review Article, Βασίλειος Α. Κόκκας - B. Kokkas, Δημήτριος Κουβέλας - Dimitrios Kouvelas, Κωνσταντίνος Λ. Παπαδόπουλος - Constantine L. Papadopoulos, Μ. Κοτούλα - M. Kotoula, Πλήρες Κείμενο στα Αγγλικά - Full Text in English
Title Identification of δ-opioid receptors at the smooth muscles of the bovine aortic media
Authors B. Kokkas, K. Papadopoulos, M. Kotoula, A. Kouyoumtzis, D. Kouvelas and A. Paradelis

Department of Pharmacology, Medical School, Aristotelian University of Thessaloniki, Greece
Citation Kokkas, B., Papadopoulos, K., Kotoula, M., Kouyoumtzis, A. et al.: Identification of δ-opioid receptors at the smooth muscles of the bovine aortic media, Epitheorese Klin. Farmakol. Farmakokinet. 5(2): 67-70 (1991)
Publication Date Received for publication: January 5, 1991

Accepted for publication: February 25, 1991
Full Text Language English
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Keywords Opioid receptors, vascular wall, methionin-5-enkephalin
Other Terms review article
Summary The influence of 4 opioid receptor agonists on Ca2+ uptake by the bovine aortic media was investigated in vitro. 45Ca was used and radioactivity was counted in a beta scintillation counter. Morphine 5pM and morphiceptin 5pM, both p-opioid receptor agonists with a very low affinity for 5-opioid binding sites, have a negligible effect on Ca3+ uptake by the preparation. Dynorphin 1-13, 5 μM, agonist of K-opioid receptors, increases Ca2+ uptake, but this action is not inhibited by naloxone 500 nM, an opioid receptor antagonist. Methionin-5-enkephalin 5 μM, a 6-opioid receptor agonist, increases Ca2+ uptake ranging from 10-12%, this action is constant and fully antagonized by naloxone 500 nM. Endothelium exerts an inhibiting action on Ca2+ uptake by the preparation and this action is diminished in the presence of methionin-5-enkephalin 5 μM. These results indicate the existence of 6-opioid receptors on the examined vascular smooth muscle: the stimulation of which results in an increase of Ca2+ uptake by the preparation.
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