Τόμος 5 (1991) – Τεύχος 2 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 5 (1991) – Issue 2 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title An unknown factor, in the rabbit serum, is measured by the R.I.A. method for digitoxin
Authors B. Kokkas, K. Papadopoulos, M. Kotoula and A. Paradelis

Department of Pharmacology, Medical School, Aristotelian University of Thessaloniki, Greece

Citation Kokkas, B., Papadopoulos, K., Kotoula, M., Paradelis, A.: An unknown factor, in the rabbit serum, is measured by the R.I.A. method for digitoxin, Epitheorese Klin. Farmakol. Farmakokinet. 5(2): 71-73 (1991)
Publication Date Received for publication: 15 December, 1990

Accepted for publication: 25 January, 1991

Full Text Language English
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Keywords Digitoxin like factors, RIA for digitoxin.
Other Terms review article
Summary An immunoactivity corresponding to 4.14±0.06 and 4.33±0.07 ng/ml of digitoxin was observed in the serum of male and female rabbits, respectively. This immunoactivity was not found in the human as well as the mouse serum. It is difficult to say if it is a cross-reaction due to an unimportant factor or an endogenous digitoxin-like substance which recognizes the digitoxin antibodies. Available bibliographic data concern findings coming only from a digoxin immunoreactivity in some fluids from animal and human sources.
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2.       MacGregor, G., Fenton, S., Alaghband-Zadeh, J., Markandu, N., Roulston, J., De Wardener, H.: Evidence for a raised concentration of a circulating sodium transport inhibitor in essential hypertension. Br. Med. J.  283: 1355 (1981)

3.       Hamlyn, J., Ringel, R., Schaeffer, J., Levinsdh, P., Hamilton, B., Kowarski, A., Blaustein, M.: A circulating inhibitor of (Na+-K+) ATPase associated with essential hypertension. Nature 100: 650 (1982)

4.       De Wardener, H., Mac Gregor, C.: The relation of a circulating sodium transport inhibitor to essential hypertension. In: Kidney in Essential Hypertension (F. Messerli, ed.), Martinus Nijhoff Publishing, Boston, 1984

5.       Blaustein, M.: The role of sodium-calcium exchange in the genesis of essential hypertension. In: Topics in Pathophysiology of Hypertension. (H. Villarreal, M. Sambhi, eds), Martinus Nijhoff Publishers, Boston, 1984

6.       Wardener, H., Mac Gregor, G.: Natriuretic hormone and essential hypertension. In: Essential Hypertension as an Endocrine Disease (C. Edwards, R. Garey, eds), Butterworth, 1985

7.       Valdes, R.: Endogenous digoxin-like immunoreactive factors. Clin. Chem. 31: 1525 (1985)

8.       Soldin, S., Papanastassiou, A., Heyes, J., Lingwood, C., Olley, P.: Are immunoassays for digoxin reliable? Clin. Biochem. 17: 317 (1984)

9.       Skogen, W., Rea, M„ Valdes, R.: Endogenous digoxin like immunoreactive factors eliminated from serum samples by immunoassay. Clin. Chem: 33: 401 (1987)

10.     Skogen, W., Rea, M., Valdes, R.: Improved interassay correlation of digoxin results in patients with and without renal failure by elimination of digoxin-like immunoreactive factors. Clin. Chem. 33: 837 (1987)

11.     Graves, S., Williams, C.: An endogenous ouabain-like factor associated with hypertensive pregnant women. J. Cln. Endocrinol. Metab. 59: 1070 (1984)

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