Τόμος 6 (1992) – Τεύχος 2 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 6 (1992) – Issue 2 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Chemistry Department, University of Athens, Panepistimioupolis Zografou, Athens, Greece

Accepted for publication: 2 May 1992

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2.       Floyd, R.A.: Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB 4: 2587 (1990)

3.       Mason, R.P., Maples, K.R., Knecht, K.T.: in vivo detection of free radicals metabolites by spin trapping. Specialist Periodical Reports. Electron Spin Resonance, vol. II B, Royal Society of Chemistry, London, 1989

4.       Janzen, E.G., Blackburn, B.J.: Detection and identification of short-lived free radicals by an Electron Spin Resonance Trapping technique. J. Am. Chem. Soc. 90: 5909(1968)

Chalfont G.R., Perkins, M.J., Horsfield, A.J.: A probe for homolytic reactions in solution. II. The polymerization of styrene. J. Am. Chem. Soc. 90: 7141 (1968)

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6.       Poyer, J.L., Floyd, R.A., McCay, P.B., Janzen, E.G., Davis, E.R.: Spin trapping of. the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of CCU and CCIaBr. Biochim. Biophys. Acta 539: 402(1978)

7.       Poyer J.L., MacCay, P.B.. Lai, E.K., Janzen E.G., Davis, E.R.: Confirmation of the assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism in vitro and in vivo. Biochem. Biophys. Res. Commun. 94: 1154 (1980)

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11.     Dianzani, M.V.: Lipid peroxidation in ethanol poisoning: a critical reconsideration. Alcohol and Alcoholism 20: 161 (1985)

12.     Slater, T.F.: Hepatotoxic effects of alcohol. In: Free Radical Mechanisms in Tissue Injury. Pion, London, pp. 171- 197,1972

13.     Albano, E„ Tomasi, A., Goria-Gatti, L., Dianzani, M.V.: Spin trapping of free radical species produced during the microsomal metabolism of ethanol. Chem.-Biol. Interactions 65: 223 (1988)

14.     Kalyanaraman, B., Mottley, C., Mason, R.P.: A direct electron spin resonance and spin trapping investigation of peroxyl radical formation by hematin/hydroperoxide systems. J- Biol. Chem. 258: 3855 (1983)

15.     McCay, P.B., Lai, E.K., Poyer, J.L., Du Bose, C.M., Janzen, E.G.: Oxygen and carbon-centered free radical formation during carbon tetrachloride metabolism. J. Biol. Chem. 259: 2135 (1984)

16.     Davies, M.J.: Applications of ESR spectroscopy to the identification of radicals produced during lipid peroxidation. Chem. Phys. Lipids 44: 149 (1987)

17.     Mason, R.P., Maples, K.R., Knecht, K.T.: In vivo detection of free radical metabolites by spin trapping. In: Specialist Periodical Reports. Electron Spin Resonance, vol. II B, Royal Society of Chemistry, p. 4, 1989.

18.     Lai, E.K., McCay, P.B., Noguchi, T., Fong, K.-L.: In vivo spin trapping of trichloromethyl radicals formed from carbon tetrachloride. Biochem. Pharmacol. 28: 2231 (1979)

19.     Mottley, C., Mason, R.P.: Nitroxide radical adducts in biology: chemistry, applications and pitfalls. In: Spin Labeling: Theory and Applications, vol. III. Berliner, L.J. (Ed.), Academic Press, New York, 1988

20.     Tomasi, A., Albano, E., Biasi, F„ Slater, T.F., Vannini, V., Dianzani, M.U.: Activation of chloroform and related trihalomethanes to radical intermediates in isolated hepatocytes and in the rat in vivo as detected by the ESR-spin trapping technique. Chem. Biol. Interactions 55: 303(1985)

21.     Lai, E.K., Crossley, C., Sridhar, R„ Misra, H.-P., Janzen, E.G., McCay, P.B.: In vivo spin trapping of free radicals generated in brain, spleen, and liver during y-radiation of mice. Arch. Biochem. Biophys. 244: 156 (1986)

22.     Reinke, L.A., Lai, E.K., Dubose, C.M., McCay, P.B.: Reactive free radical generation in vivo in the heart and liver of ethanolfed rats: correlation with in vitro radical formation. Proc. Natl. Acad. Sci. USA 84: 9223 (1987)

23.     Maples, K.P., Jordan, S.J., Mason, R.P.: In vivo rat hemoglobin thiyl free radical formation following phenylhydrazine administration. Mot. Pharmacol. 33: 344 (1988)

24.     Maples, K.P., Jordan, S.J., Mason, R.P.: In vivo rat hemoglobin thiyl radical formation following the administration of phenylhydrazine and hydrazine-based drugs. Durg Metab. and Dispos. 16: 799 (1988)

25.     Reinke, L.A., Janzen, E.G.: Detection of spin adducts in blood after administration of carbon tetrachloride to rats. Chem.-Biol. Interactions 78: 155 (1991 )

26.     Connor, H.D., Thurman, R.G., Galizi, M.D., Mason, R.P.: The formation of a novel free radical metabolite from CCU in the perfused rat liver and in vivo. J. Biol. Chem. 261: 4542 (1986)

27.     Knecht, K.T., Mason, R.P.: In vivo radical trapping and billiary secretion of radical adducts of carbon tetrachloride-derived free radical metabolites. Drug Metab. and Dispos. 76: 313 (1988)

28.     Kennedy, C.H., Hatch, G.E., Slade, R., Mason, R.P.: Application of the EPR spin trapping technique to the detection of radicals produced in vivo during inhalation exposure of rats to ozone. 5^th Biennial Meeting of the International Society for Free Radical Research. Abstract. Free Radical Biol. Med. 9 (SI), 114 (1990)

29.     O. Hayaishi, E. Niki, M. Kondo, T. Yoshikawa (eds): Medical, Biochemical and Chemical Aspects of Free Radicals. 4^th Biennial General Meeting of the Society for Free Radical Research, Kyoto, Japan, 9-13 April 1988, Elsevier, Amsterdam, 1989.

30.     W.A. Pryor, K.J.A. Davies (eds): Oxidative Damage and Repair. 5^th Biennial Meeting of the International Society for Free Radical Research. Pasadena, California, November 14-20, 1990. Abstract Free Radical Biol. Med. 9 (S I), 1990

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