Τόμος 19 (2005) – Τεύχος 1 – Άρθρο 7 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 19 (2005) – Issue 1 – Article 7 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

 

Title Effect of nicotinamide on C-peptide levels in insulin-dependent diabetes mellitus
Authors Maria Gourni¹, Zoi Roupa², Christine Marvaki¹, Alexander Ardavanis³, Penelope Sotiropoulou, Panayota Gourni and Christos Bartsokas6

1.       Nursing Department, Educational Technological Institute of Athens, Athens, Greece

2.      Educational Technological Institute of Larissa, Greece

3.      Anticancer Institute Agios Savas, Athens, Greece

4.      Department of Social Services, Bank of Greece, Athens, Greece

5.      Pamakaristos Hospital, Athens, Greece

6.      Nursing Department, University of Athens, Athens, Greece

Citation Gourni, M., Roupa, Z., Marvaki, C., Ardavanis, A., Sotiropoulou, P. et al.: Effect of nicotinamide on C-peptide levels in insulin-dependent diabetes mellitus, Epitheorese Klin. Farmakol. Farmakokinet. 19(1): 37-42 (2005)
Publication Date Received for publication: 15 January 2005

 Accepted for publication: 8 February 2005

Full Text Language English
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Keywords Insulin-dependent diabetes mellitus, Nicotinamide, C-peptide.
Other Terms review article
Summary The aim of this study is to assess the effect of nicotinamide to c-peptide levels in children during the first six weeks of insulin-dependent diabetes mellitus (IDDM). Thirty-eight children and adolescents, with recent diagnosis (≤ 6 weeks) of IDDM were studied. Patients were randomized in two groups. In Group A patients received insulin and placebo, while in group B insulin and nicotinamide. Serum c-peptide levels were measured at 0, 3, 6, 9 and 12 months. The total dose of insulin administered the day preceding each sampling was recorded. Results: there was a significant difference between the various average values of c-peptide levels during the second trimester with p=0.01 for group A and p=0.02 for group B. No statistically significant difference was found between the two groups. Similar findings were observed for insulin-dose. Toxicity was negligible and similar in both groups. In conclusion, the treatment of newly diagnosed IDDM with NA does not significantly affect c- peptide levels for a period of time exceeding 6 months. However, this small-size pilot study should be confirmed by a large randomized study with different design involving NA treatment before clinical IDDM.
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