| Title | Experience with nifedipine with or without propranolol in the treatment of pregnancy induced hypertension | |
| Authors | Lygeri Soubassi¹,², Dimitris Chaniotis¹ and Sofia Soubassi¹
1. Department of Nephrology, Hygeia Hospital, Athens, Greece 2. Department of Nephrology, Alexandra Maternity Hospital, Athens, Greece |
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| Citation | Soubassi, L., Chaniotis, D., Soubassi, S.: Experience with nifedipine with or without propranolol in the treatment of pregnancy induced hypertension, Epitheorese Klin. Farmakol. Farmakokinet. 19(3): 149-153 (2005) | |
| Publication Date | Accepted for publication: 5 November 2005 | |
| Full Text Language | English | |
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| Keywords | Pregnancy, nifedipine, propranolol, hypertension. | |
| Other Terms | review article | |
| Summary | Nifedipine was administered orally (10-20mg ID) as first line drug therapy to 10 patients (pts) hospitalized for severe pregnancy induced hypertension (PIH), (BP≥160/110 mmHg) and 8 pts with preeclampsia (PE). Antenatal surveillance included sequential: serum biochemical parameters, ultrasound; fetal cardiotocograms, biophysical profile and Doppler velocimetry. In 3 pts with PIH and 3 with PE a second drug (Propranolol 20-40 mg ID) had to be added in order to achieve satisfactory BP control. The mean gestational age at the initiation of therapy was 32 weeks (range 23-38), the mean duration of therapy was 28 days (range 5-80) and the mean gestational age at delivery was 37 weeks (range 31-40). The mean reduction in BP was 20mmHg for both the systolic and diastolic components, without any significant changes in the above mentioned parameters. Only one intrauterine death was observed in a severely ill pts with preexisting lymphoma. Four infants from PE and one from a PIH mother were below the 10th centile for gestational age. One infant from a PE mother developed idiopathic respiratory distress syndrome (IRDS) from which he recovered. Both drugs were well tolerated by all pts. Although this was an uncontrolled study, our preliminary results suggest that Nifedipine, with or without Propranolol, can be safely administered to pts with pregnancy related hypertension, under close fetal surveillance. | |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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