Τόμος 7 (1993) – Τεύχος 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 7 (1993) – Issue 1 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Department of Biology, University of Athens and Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, Athens, Greece

Accepted for publication: 2 December 1992

pharmakonpress[at]pharmakonpress[.]gr

2.    Palmiter, R.D., Brinster, R.L.: Germiline transformation of mice. Ann. Rev. Genet. 20: 465 (1986)

3.    Hogan, B., Constantini, F., Lacy, E.: Manipulating the Mouse Embryo. Cold Spring Harbor Laboratory (1986)

4.    Jaenisch, R.: Transgenic animals. Science 240: 1468 (1988)

5.    Hanahan, D.: Transgenic mice as probes into complex systems. Science 246: 1266 (1989)

6.    Jordon, J.W.: Transgenic animals. Inter. Rev. Cytol. 115: 171 (1989)

7.    Grosveld, F. and Kolias, G. (eds.): Transgenic animals. Academic Press, San Diego (1992)

8.    Watson, J.D., Gilman, M., Witkowski, J., Zoller, M.: Recombinant DNA. W.H. Freeman and Company, New York (1992)

9.    Kollias, G., Grosveld, F.: The study of gene regulation in transgenic mice. In: Transgenic Animals (F. Grosveld and G. Kolias, eds.), p. 79, Academic Press, San Diego (1992)

10.  Clark, A.J., Simons, J.P., Wilmut, I.: Germ line manipulation: Applications in Agriculture and Biotechnology. In: Transgenic Animals (F. Grosveld and G. Kolias, eds.) p. 247. Academic Press, San Diego (1992)

11.  Kioussis, D.: Oncogenesis and trangenic mice. In: Transgenic Animals (F. Grosveld and G. Kolias, eds.) p. 195. Academic Press, San Diego (1992)

11a. Schedl, A., Montoliu, L., Kelsey. G.. Schütz, G.: A yeast artificial chromosome covering the tyrosinase gene confers copy number – dependent expression in trangenic mice. Nature 362: 258 (1993)

12.  Gossler, A., Doetschman, T„ Korn, R., Serfling, E. and Kemler, R.: Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc. Nat. Acad. Sei. 83: 9065 (1986)

12a. Jakobovits, A., Moore, A.L., Green, L.L., Vergara, G. J., Maynard – Gurrie, C.E., Austin, H.A., Klapholz, S.: Germ-line transmission and expression of human-derived yeast artificial chromosome. Nature 362: 255 (1993)

13.  Kollias, G., Wrighton, N., Hurst, J. and Grosveld, F.: A tissue and developmental specific enhancer is located downstream from the human ß-globin gene. Nucleic Acids Res. 15: 5739 (1987)

14.  Swift, G.H., Hammer, R.E., MacDonald, R.J., Brinster, R.L.: Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell 38: 639 (1984)

15.  Brinster, R.L., Allen, J.M., Behringer, R.R., Gelinas, R.E., Palmiter, R.D.: Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad. Sci. 85: 836 (1988)

16.  Hanahan, D.: Heritable formation of pancreatic β-cell tumoris in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315: 115 (1985)

17.  Palmiter, R.D., Behringer, R.R., Quaife, C.J., Maxwell, F., Maxwell, I.H., Brinster, I.H.: Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 50: 435 (1987)

18.  Borrelli, E., Heyman, R., Hsi, M., Evans, R.M.: Targeting of an inducible toxic phenotype in animal cells. Proc. Natl. Acad. Sci. 85: 7572 (1988)

19.  Bernstein, A., Breitman, M.: Genetic ablation in transgenic mice. Mol. Biol. Med. 6: 523 (1989)

20.  Breitman, M.L., Rombola, H., Maxwell, I.H., Klintworth,G.K.K., Bernstein, A.: Genetic ablation in transgenic mice with an attenuated diptheria toxic A gene. Mol. Cell. Biol. 10: 474 (1990)

21.  Heyman, R.A., Borrelli, E., Lesley, J., Anderson, D., Richman, D.D., Baird, S.M., Hyman, R., Evans, R.M.: Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency. Proc. Natl. Acad. Sci. 86: 2698 (1989)

22.  Woychik, R.P., Stewart, T.A., Davis, I.G., D’Eustachio, P., Leder, P.: An inherited limb deformity created by insertional mutagenesis in a transgenic mouse. Nature 318: 36 (1985)

23.  Mansour, S.L., Thomas, K.R., Capecchi, M.R.: Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to nonselectable genes. Nature 336: 348 (1988)

24.  Balling, R., Mutter, G., Gruss, P., Kessel, M.: Craniofacial abnormalities induced by ectopic expression of the homeobox gene Mox. 1.1. in transgenic mice. Cell 58: 337 (1989)

25.  Palmiter, R.D., Norstedt, G., Gelinos, R.E., Hammer, R.E., Brinster, R.L.: Metallothionein-human GH fusion genes stimulate growth of mice. Science 222: 809 (1983)

26.  Pursei, V.G., Pinkert, C.A., Miller, K.F., Bolt, D.J., Campbell, R.G., Palmiter, R.D., Brinster, R.L., Hammer, R.E.: Genetic engineering of livestock. Science 244: 1281 (1989)

27.  Hammer, R.E., Brinster, R.L., Rosenfels, M.G., Mayo, K.E.: Expression of human growth hormone releasing factor in transgenic mice results in increased somatic growth. Nature 315: 413 (1985)

28.  Harris, S., McClenaghan, M., Simons, J.P., Ali, S. and Clark, A.J.: Gene expression in the nammary gland. J. Reprod. Fert. 88: 707 (1990)

29.  Rees, W.D., Flint, H.J., Fuller, M.F.: A molecular biology approach to reducing dietary amino acid needs. Biotechnology 8: 629 (1990)

30.  Ward, K.A., Murray, J.D., Nancarrow, C.D.: The insertion of foreign genes into animal cells. Biotechnology for Livestock Production, FAO Animal Production and Health division, p. 17, Plenum Press, New York (1989)

31.  Stacey, A.J., Bateman, J., Choi, T., Mascara, T., Cole, W., Jaenisch, R.: Perinated lethal osteogenesis imper-fecta in transgenic mice bearing and engineered mutant pro-a1(l) collagen gene. Nature 332: 131 (1988)

32.  Keffer, J., Probert, L., Castaris, H., Georgopoulos, S., Kaslatis, E., Kioussis, D., Kolias, G., Transgenic mice expressing human tumor necrosis factor: a predictive genetic model of arthritis. EMBO J. 10: 4025 (1991)

33.  Small, J.A., Scangow, G.A., Cork, L., Jay, G., Khoury,G.: The early region of human papovirus JC induces dysmyelination in transgenic mice. Cell 46: 13 (1986)

34.  DeCaprio, J.A., Ludlow, J.W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E. and Livingston, D.M.: SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility locus. Cell 54: 275 (1988)

35.  Messing, A., Chen, H.Y., Palmister, R.D., Brinster, R.L.: Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice. Nature 316: 461 (1985).

36.  Teitelman, G., Alpert, S., Hanahan, D.: Proliferation, senescence and neoplastic progression of beta cells in hyperplastic pancreatic islets. Cell 52: 97 (1988)

37.  Mahon, K.A., Chepelinsky, A.B., Khillan, J.S., Overbeek, P.A., Piatigorsky, J., Westphal, H.: Oncogenesis of the lens in transgenic mice. Science 235: 1622 (1987)

38.  Sinn, E., Muller. W., Pattengale, P.. Tepler, I., Wallace, R., Leder, P.: Coexpression of MMTV/v-Haras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49: 465 (1987)

pharmakonpress[at]pharmakonpress[.]gr

pharmakonpress[at]pharmakonpress[.]gr