| Title | Subcutaneous bioavailability of carbisocaine in rats determinated by frequency response method | |
| Authors | M. Durisova¹, L. Dedik², L. Bohm², T. Trnovec³, Z. Kallay³ and V. Faberova⁴
1. Institute of Experimental Pharmacology, Slovak Academy of Sciences 842 16 Bratislava, Slovak Republic, 2. Faculty of Mechanical Engineering, Slovak Technical University, 812 31 Bratislava, Slovak Republic, 3. Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovak Republic, 4. Drug Research Institute, 900 01 Modra, Slovak Republic |
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| Citation | Durisova, M., Dedik, L., Bohm, L., Trnovec, T., Kallay, Z.: Subcutaneous bioavailability of carbisocaine in rats determinated by frequency response method, Epitheorese Klin. Farmakol. Farmakokinet. 9(1): 25-31 (1995) | |
| Publication Date | Accepted for publication: 23 March 1995 | |
| Full Text Language | English | |
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| Keywords | Frequency response method, weighting function, local anesthetics, subcutaneous administration, bioavailability, absorption kinetics, mean residence time. | |
| Other Terms | review article | |
| Summary | Carbisocaine, a prospective local anesthetic agent, was administered to rats intravenously and subcutaneously in a dose of 2.43 mg.kg-1. The optimal frequency model of the system describing carbisocaine pathway into the systemic circulation after subcutaneous administration, and point estimates of its parameters were selected using the CXT program and the frequency response method. The method is based on the approximation of the frequency response of the linear or linearized dynamic system, measured or calculated from input-output measurements, by the frequency model of the system transfer function, in the form of the ratio of the two frequency-dependent polynomials. The polynomials mentioned are general representatives of all models described by the sets of linear differentiaI equations with constant coefficients. The mean residence time of carbisocaine in the system studied was estimated on the basis of the selected system frequency model as 392.4 min. The estimation of the extent of carbisocaine subcutaneous bioavailability yielded the value of 0.434. The system weighting function describing the rate of carbisocaine subcutaneous bioavailability was estimated in an analytical form. This showed four distinctive phases and a rapid initial peak of nearly 0.0017 units dose/min, recorded approximately 2.5 min after the drug administration. | |
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