| Title | Utilization of frequency response method in pharmacokinetics | |
| Authors | Ladislav Dedik¹ and Maria Durisova²
1. Faculty of Mechanical Engineering, Slovak Technical University, SK-812 31 Bratislava, Slovak Republic 2. Institute of Experimental Pharmacology, Slovak Academy of Sciences, SK-832 16 Bratislava, Slovak Republic |
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| Citation | Dedik, L., Durisova, M: Utilization of frequency response method in pharmacokinetics, Epitheorese Klin. Farmakol. Farmakokinet. 7(3): 131-137 (1993) | |
| Publication Date | Received for publication: 1 December 1993
Accepted for publication: 20 December 1993 |
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| Full Text Language | English | |
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| Keywords | Linear dynamic system, frequency response method, extent of bioavailability, rate of bioavailability, gentamicin. | |
| Other Terms | review article | |
| Summary | The paper presents the demonstration of applicability of the frequency response method in pharmacokinetics. The method, common in system engineering, in based on an approximation of the frequency response of a linear dynamic system, calculated from input-output measurements, by a frequency model of the system transfer function in the frequency domain. The method is demonstrated on the estimation of the rate and extent of gentamicin bioavailability after intratracheal administration to guinea pigs. The estimate of the rate of gentamicin intratracheal bioavailability did not decrease monotonously after the maximum of about 2.2 – 2.5 unit of dose/hr recorded approximately 0.1 hr after drug administration, but it showed a marked additional peak approximately at 0.3 hr after administration and possible peaks in the further time period. The estimate of the extent of gentamicin intratracheal bioavailability of 93.4% was obtained, thus the conclusion could be made that gentamicin injected intratracheally to guinea pigs is almost completely available. | |
| References | 1. Schoukens, J., Pintelon, R.: Identification of linear systems. A practical guide for accurate modelling. Pergamon Press, London, 1991
2. Smolen, V.F.: A frequency response method for pharmacokinetic model identification. In: Kinetic Data Analysis (L. Endrenyi, ed.), Plenum Press, New York, 1981 3. Smolen, V.F.: A generalized numerical denonvolution procedure for computing absolute bioavailability-time profiles. In: Kinetic Data Analysis (L. Endrenyi, ed.), Plenum Press, New York, 1981 4. Finkelstein, L., Carson, E.R.: Mathematical modeling of dynamic and biological systems. Research Studies Press, London, 1985 5. van Rossum, J.M., de Bie, J.E.G.M., van Lingen, G., Teeuwen, H.W.A.: Phrarmacokinetics from dynamic systems’ point of view. J. Pharmacokinet, Biopharm. 17: 365-392 (1989) 6. Trnovec, T., Durisova, M., Kallay, Z., Navarova, J., Tomcikova, M., Kettner, M., Faltus, G., Erichleb, M.: Pharmacokinetics of gentamicin administered intratracheally or as an inhalation aerosol to guinea pigs. Drug Metabol. Disp. 12: 641-644 (1984) 7. Dedik, L., Durisova, M.: Modeling of continuous systems in frequency domain. Kybernet. Informat 5: 15-20 (1992) 8. Dedik, L., Durisova, M.: CTX-(Complex Tools for the Analysis of Linear Dynamic Systems), a new software for the pharmacokinetic analysis in the frequency domain. International Symposium Novel Concepts in Pharmacokinetics, Smolenice, Slovak Republic, Book of Abstracts, p. 7,1992 9. Durisova, M., Dedik, L., Balan, M.: Assessment of extent and rate of drug bioavailability using the frequency response method. International Symposium Novel Concepts in Pharmacokinetics, Smolenice, Slovak Republic, Book of Abstracts, p. 9,1992 10. Plusquellec, Y., Bousquet, L.: Time-delay for two compartment models used for study of enterohepatic circulation of drugs. IEEE Trans. Biomed. Engin. 31: 469-472 (1984) |
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Online ISSN 1011-6575
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1993 – ANNUAL SUBSCRIPTION 1993 | |
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