Τόμος 8 (1994) – Τεύχος 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 8 (1994) – Issue 1 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Institute of Biological Research and Biotechnology, The National Hellenic Research Foundation, 48 Vas. Constantinou Ave. 116 35 Athens, Greece

Accepted for publication: 2 December 1993

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2.    Van der Voet, G.B., Marani, E., Tio, S. and de Wolff, F.A.: Aluminum neurotoxicity. In: Histo- and Cytochemistry as a Tool in Environmental Toxicology (Graumann, W. and Drukker, J. eds) p.235, Gustav Fischer Verlag, Stuttgart, 1991

3.    Zatta, P.F., Nicolini, M. and Corain, B.: Aluminum (III) toxicity and blood-brain barrier permeability. In: Aluminum in Chemistry, Biology and Medicine (Nicolini, M. et al eds) p.97, Raven Press, New York, 1991

4.    Savory, J., Herman, M.M., Katsetos, C.D. and Wills, M.R.: Aluminum and neurodegenerative disorders. In: Aluminum in Chemistry, Biology and Medicine (Nicolini, M. et al eds) p.45, Raven Press, New York, 1991

5.    Martin, R.B.: The chemistry of aluminum as related to biology and medicine, Clin. Chem. 32: 1797 (1986)

6.    Macdonald, T,L. and Martin, R.B.: Aluminum in biological systems. Trends Biochem Sci. 13: 15 (1988)

7.    Flaten, T.P. and Garruto, R.M.: Polynuclear ions in aluminum toxicity. J. Theor. Biol. 156: 129 (1992)

8.    Rao, G.V. and Rao, K.S.J.: Evidence for a hydroxy-aluminum polymer (Αl13) in synaptosomes. FEBS Lett. 311, 49 (1992)

9.    Yokel, R.A., Datta, K. and Jackson, E.G.: Evaluation of potential aluminum chelators in vitro by aluminum solubilization ability, aluminum mobilization from transferrin and the octanol/aqueous distribution of the chelators and their complexes with aluminum. J. Pharmacol. Exp. Ther. 257: 100 (1991)

10.  Birchall, J.D.: The toxicity of aluminum and the effect of silicon on its bioavailability. In: Aluminum in Chemistry, Biology and Medicine (Nicolini, M. et al eds) p.3, Raven Press, New York, 1991.

11.  Chabre, M.: Aluminofluoride and beryllofluoride complexes: new phosphate analogs in enzymology. Trends Biochem. Sci 15: 6 (1990)

12.  Monteagudo. F.S.E., Cassidy, M.J.D. and Fold, P.I.: Recent developments in aluminum toxicology. Med. Toxicol. Adv. Dr. Exp. 4: 1 (1989)

13.  Davenport, A. and Goodall, R.: Aluminum and dementia. Lancet 339: 1236 (1992)

14.  Slanina, P., Falkeborn, Y., Freeh, W. and Cedergren, A.: Aluminum concentration in the brain and bone of rats fed citric acid, aluminum citrate or aluminum hydroxide. Fd. Chem. Toxicol. 22: 391 (1984)

15.  Slanina, P., Freeh, W., Berbardson, A., Cedergren, A. and Mattsson, P.: Influence of dietary factors on aluminum absorption and retention in the brain and bone of rats. Acta Pharmacol. Toxicol. 56: 331 (1985)

16.  Slanina, P., Freeh, W., Ekstrom, L., Loof, L., Slorach, S. and Cedergren, A.: Dietary citric acid enhances absorption of aluminum in antacids. Clin. Chem. 32: 539 (1986)

17.  Akeson, M.A. and Munns, D.N.: Lipid bilayer permeation by neutral aluminum citrate and by three a-hydroxy carboxylic acids. Biochim. Biophys. Acta 984: 200 (1989)

18.  Wisniewski, H.M. and Kozlowski, P.B.: Evidence for blood-brain-barrier changes in senile dementia of Alzheimer type (SDAT). Ann. N. Y. Acad. Sci. 396: 119 (1982)

19.  Roskams, A.J. and Connor, J.R.: Aluminum access to the brain: a role for transferrin and its receptor. Proc. Natl. Acad. Sci. USA 87: 9024 (1990)

20.  Kubal, G., Mason, A.B., Sadler, P., Tucker, A. and Woodworth, R.C.: Uptake of Al³⁺ into the N-lobe of human serum transferrin. Biochem. J. 285: 711 (1992)

21.  Baker, E., Rumball, S.V. and Anderson, B.F.: Transferrins: insights into structure and function from studies in lactoferrin. Trends Biochem. Sci. 12: 350 (1987)

22.  Crichton, R.R.: Proteins of iron storage and transport. Adv. Protein Chem. 40: 281 (1990)

23.  Cochran, M., Coates, J. and Neoh, S.: The competitive equilibrium between aluminum and ferric ions for the binding sites of transferrin. FEBS Lett. 176: 129 (1987)

24.  Perl, D.P. and Good, P.F.: Aluminum, Alzheimer’s disease and the olfactory system. Ann. N.Y. Acad. Sci 640: 8 (1991)

25.  Ganrot P.O.: Metabolism and possible health effects of aluminum. Environ. Health Perspect. 65: 363 (1986)

26.  Exley, C. and Birchall, J.D.: The cellular toxicity of aluminum. J. Theor. Biol. 159: 83 (1992)

27.  Hemmings, H.C.,Jr., Nairn, A.C., McGuinness, T.L., Huganir, R.L. and Greengard, P.: Role of protein phosphorylation in neuronal signal transduction. FASEB J. 3: 1583 (1989)

28.  Vierstra, R. and Haug, A.: The effect of Al³+ on the physical properties of membrane lipids in Thermoplasma acidophifum. Biochem, Biophys. Res. Commun. 84: 138 (1978)

29.  Shi, B. and Haug, A.: Aluminum uptake by neuroblastoma cells. J. Neurochem. 55: 551 (1990)

30.  Akeson, M., Munns, D.N. and Burau, R.G.: Adsorption of Al³⁺ to phosphatidylcholine vesicles. Biochim. Biophys. Acta 986: 33 (1989)

31.  Colombini, M.: Aluminum and membrane channels. In: Aluminum in Chemistry, Biology and Medicine (Nicolini M. et al eds) p.33, Raven Press, New York, 1991

32.  Arispe, N., Rojas, E. and Pollard, H.B.: Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: Blockade by tromethamine and aluminum. Proc. Natl. Acad. Sci. USA 90: 567 (1993)

33.  King, R.G.: Do raised brain aluminum levels in Alzheimer’s dementia contribute to cholinergic neuronal deficits. Med. Hypotheses 14: 301 (1984)

34.  Marquis, J.K. and Lerrick, A.J.: Noncompetitive inhibition by aluminum, scandium and yttrium of acetylcholinesterase from Electrophorus electricus. Biochem. Pharmacol. 31: 1437 (1982)

35.  Candura, S.M., Castoldi, A.F., Manzo, L. and Costa, L.G.: Interaction of aluminum ions with phosphoinositide metabolism in rat cerebral cortical membranes. Life Sci. 49: 1245 (1991)

36.  Schofl, C., Sanchez-Bueno, A., Dixon, C.J., Woods, N.M., Lee, J.A.C., Cuthbertson, K.S.R., Cobbold, P.H. and Birchall, J.D.: Aluminum perturbs oscillatory phosphoinositide-mediated calcium signalling in hormone-stimulated hepatocytes. Biochem. J. 269. 547 (1990)

37.  Shears, S.B., Dawson, A.P., Loomis-Husselbee, J.W, and Cullen, P.J.: The perturbation, by aluminum of receptor generated calcium transients in hepatocytes is not due to effects of lns(1,4,5) P3-stimulated Ca²⁺ release or Ins(1,4,5)P3 metabolism by the 5-phosphatase and 3-kinase. Biochem. J. 270: 837 (1990)

38.  Shi, B. and Haug, A.: Aluminum interferes with signal transduction in neuroblastoma cells, Pharmacol. Toxicol. 71: 308 (1992)

39.  Siegel, N. and Haug, A.: Aluminum interaction with calmodulin. Evidence for altered structure and function from optical and enzymatic studies. Biochim .Biophys. Acta 744: 36 (1983)

40.  Forbes, W.F., Hayward, L.M. and Agwani, N.; Dementia, aluminum and fluoride. Lancet 338: 1592 (1991)

41.  Miller, J.L., Hubbard, C.M., Litman, B.J. and Maddonald, T.L.: Inhibition of transducin activation and guanosine triphosphatase activity by aluminum ion. J. Biol. Chem. 264: 243 (1989)

42.  Joshi, J.G.: Aluminum, a neurotoxin which affects diverse metabolic reactions. Biofactors 2: 163 (1990)

43.  Joshi, J.G.: Neurochemical hypothesis: Participation by aluminum in producing critical mass of colocalized errors in brain leads to neurological disease. Comp. Biochem. Physiol. 100C: 103 (1991)

44.  Fleming, J. and Joshi, J.G.: Ferritin: The role of aluminum in ferritin function. Neurobiol. Aging 12: 413 (1991)

45.  Fleming, J. and Joshi, J.G.: Ferritin: Isolation of aluminum-ferritin complex from brain. Proc. Natl. Acad. Sci. USA 84: 7866 (1987)

46.  San-Marina, S., Nicholls, D.M., Kruck, T.P.A. and McLachlan, D.R.C.: Aluminum effects on synthesis of brain metal binding proteins. FASEB J. 4: A1014 (1990)

47.  Lai, J.C.K. and Blass, J.P.: Inhibition of brain glycolysis by aluminum. J. Neurochem. 42: 438 (1984)

48.  McLachlan, D.R.C.: Calcium-aluminum interactions in brain disease. In: Normal Aging, Alzheimer’s Disease and Senile Dementia. Aspects on Etiology, Pathogenesis, Diagnosis and Treatment (Gottfries, C.G., ed) p. 105, Editions de l’ Universite de Bruxelles, Bruxelles, 1985

49.  Cho, S.W. and Kim, G.Y.: Activation of acid ribonuclease from bovine brain by aluminum. J. Biochem. 110: 802 (1991)

50.  Trenkner, E., Liu, D. and Wisniewski, H.W.: Aluminum neurotoxicity is mediated by NMDA excitotoxicity. J. Neurochem. 61, Suppl: 533 (1993)

51.  Provan, S.D. and Yokel, R.A.: Aluminum inhibits glutamate release from transverse rat hippocampal

slices: Role of G proteins, Ca channels and protein kinase C, Neurotoxicology 13: 413 (1992)

52.  Langui, D., Probst, A., Anderson, B., Brian, J.-P. and Ulrich, J.: Aluminum-induced tangles in cultured rat neurones. Enhanced effect of aluminum by addition of maltol. Acta Neuropathol. 80: 649 (1990)

53.  Edwardson, J.A., Ferrier, I.N., McArthur, F.K., McKeith, I.G., McLaughlin, I., Morris, C.M., Mount- fort, S.A., Oakley, A.E., Taylor, G.A., Ward, M.K. and Candy, J.M.: Alzheimer’s disease and the aluminum hypothesis. In: Aluminum ion Chemistry, Biology and Medicine (Nicolini, M. et al eds) p.85, Raven Press, New York, 1991

54.  Shea, T.B., Balikian, P. and Beermann, M.L.: Aluminum inhibits neurofilament protein degradation by multiple cytoskeleton-associated proteases. FEBS Lett. 307: 195 (1992)

55.  Mesco, E.R., Kachen, C. and Timiras, P.S.: Effects of aluminum on tau proteins in human neuroblastoma cells. Mol. Chem. Neuropathol. 14: 199 (1991)

56.  Kuroda, Y., Kawahara, M., Ichikawa, M., Muramoto, K., Kobayashi, K. and Mori, H.: Aluminum as a risk factor for Alzheimer’s disease: Aluminum causes accumulation of β amyloid protein and tau and loss of synapses in cultured cortical neurons. J. Neurochem. 61, Suppl.: 5178 (1993)

57.  Shigematsu, K. and McGeer, P.L.: Accumulation of amyloid precursor protein in damaged neuronal processes and microglia following intracerebral administration of aluminum salts. Brain Res. 593: 117 (1992)

58.  Mattson, M.P., Lovell, M.A., Ehmann, W.D. and Markesbery, W.R.: Effect of elevated intraneuronal Αl³⁺ and Ca²⁺ levels on cell survival and tau immunoreactivity in cultured neurons. J. Neuropathol. Exp. Neurol. 51: 328 (1992)

59.  Brion, J.-P.: The pathology of neuronal cytoskeleton in Alzheimer’s disease, Biochim. Blophys. Acta 1160, 134 (1992)

60.  Mantyh, P.W., Ghiiardi, J.R., Rogers, S., De-Master, E., Allen, C.J., Stimson, E.R. and Maggio, J.E.: Aluminum, iron and zinc ions promote aggregation of physiological concentrations of β-amyloid peptide. J. Neurochem. 61: 1171 (1993)

60a.Kawahara, M., Muramoto, K., Kobayashi, K., Mori, H. and Kuroda, Y.: Aluminum promotes the aggregation of Alzheimer’s amyloid β-protein In vitro. Biochem. Blophys. Res. Comm. 198: 531 (1994)

61 MacDonald, T.L., Humphreys, W.G. and Martin, R.B.: Promotion of tubulin assembly by aluminum ion in vitro. Science 236: 183 (1987)

62.  Scott, C.W., Fieles, A,, Sygowski, L.A. and Caputo, C.B.: Aggregation of tau proteins by aluminum. Brain Res 628: 77-84 (1993)

62a. Abdel-Ghany, M., El-Sebae, A.K. and Shalioway, D.: Aluminum-induced nonenzymatic phosphor-incorporation into human tau and other proteins. J. Biol Chem. 268: 11976 (1993)

63.  Diaz-Nido, J. and Avila, J.: Aluminum induces the in vitro aggregation of bovine brain cytoskeletal proteins. Neurosci. Lett. 110: 221 (1990)

64.  Candy, J.M., Oakley, A.E. and Edwardson, J.A.: Amorphous aluminosilicates promote nucléation of amyloid β protein and tachykinins. Biochem. Soc. Trans. 21: 535 (1992)

65.  Cohen, P.: The role of protein phosphorylation in neural and hormonal control of cellular activity. Nature 296: 613 (1982)

66.  Edelman, A.M., Blumenthal, D.K. and Krebs, E.G.: Protein serine/threonine kinases. Annu. Rev. Biochem. 56: 567 (1987)

67.  Walaas, S.I. and Greengard, P.: Protein phosphorylation and neuronal function. Pharmacol. Rev. 43: 299 (1991)

68.  Saitoh, T., Masliah, E., Jin, L.-W., Cole, G.M., Wieloch, T. and Shapiro, I.P.: Biology of disease. Protein kinases and phosphorylation in neurologic disorders and cell death. Lab. Invest. 64: 596 (1991)

69.  Nixon, R.A. and Sihag, R.K.: Neurofilament phosphorylation: a new look at regulation and function. Trends Neurosci. 14: 501 (1991)

70.  Johnson, G.V.W, and Jope, R.S.: Phosphorylation of rat brain cytoskeletal proteins is increased after orally administered aluminum. Brain Res. 456: 95 (1988)

71.  Johnson, G.V.W., Gogdill, K.W. and Jope, R.S.: Oral aluminum alters in vitro protein phosphorylation and kinase activities in rat brain. Neurobiol. Aging 11: 209 (1990)

72.  Caputo, C.B., Sygowski, L.A., Scott, C.W., Johnson, G.V.W., Brunner, W.F. and Salama, A.I.: Changes in protein kinase activities following aluminum administration to aged rats. Brain Dysfunct. 2: 297 (1989)

73.  Shea, T.B., Beermann, M.L. and Nixon, R.A.: Aluminum alters the electrophoretic properties of neurofilament proteins: Role of phosphorylation state. J. Neurochem. 58: 542 (1992)

74.  Leterrier, J.F., Laugui, D., Probst, A. and Ulrich, J.: A molecular mechanism for the induction of neurofilament bundling by aluminum ions. J, Neurochem. 58: 2060 (1992)

75 .Nixon, R.A., Clarke, J.F., Logvinenko, K.B., Tan, M.K.H., Hoult, M. and Grynspan, F.: Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes. J. Neurochem. 55: 1950 (1990)

76.  Yamamoto, H., Saitoh, Y., Yasugawa, S. and Miyamoto, E.: Dephosphorylation of τ factor by protein phosphatase 2A in synaptosomal cytosol fractions and inhibition by aluminum. J. Neurochem. 55: 683 (1990)

77.  Geladopoulos, T.P. and Sotiroudis, T.G.: Interaction of aluminum ions with phosvitin. J. Inorg. Biochem. 54: 247-256 (1994)

78 .Rao, K.S.J., Rao, B.S., Vishnurardhan, D. and Prasad, K.V.S.: Alteration of superhelical state of DNA by aluminum (Al). Biochim. Biophys. Acta 1172: 17 (1993)

79.  Perl, D.P. and Brody, A.R.: Alzheimer’s disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 208: 297 (1980)

80.  Perl, D., Gajdusek, D.C., Garruto, R.M., Yanagihara, R.T. and Gibbs, C.J.: Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Science 217: 1053 (1982)

81.  Crapper, D.R., Quittkat, S., Krisnan, S.S., Dalton, A.J. and DeBoni, U.: Intranuclear aluminum content in Alzheimer’s disease, dialysis encephalopathy and experimental aluminum encephalopathy. Acta Neuropathol. 50: 19 (1980)

82.  DeBoni, U., Scott, J.W. and Crapper, D.R.: Intracellular aluminum binding. Histochemical study. Histochemistry 40: 31 (1974)

83.  Wen, G.Y. and Wisniewski, H.M.: Histochemical localization of aluminum in the rabbit CNS. Acta Neuropathol. 68: 175 (1985)

84.  Karlik, S.J., Eichhorn, G.L., Lews, P.N. and Crapper, D.R.: Interaction of aluminum species with deoxyribonucleic acid. Biochemistry 19: 5991 (1980)

85.  Dobson, C.B., Templar, J., Day, J.P. and Itzaki, R.F.: Aluminum and Alzheimer’s disease: sites of aluminum-binding in human neuroblastoma cells. Biochem. Soc. Trans. 21: 321S (1993)

86.  Lukiw, W.J., Kruck, T.P.A. and McLachlan, D.R.C.: Alterations in human linker histone-DNA binding in the presence of aluminum salts in vitro and in Alzheimer’s disease. Neurotoxicology 8: 291 (1987)

87.  DeBoni, U., Seger, M. and McLachlan, D.R.C.: Functional consequences of chromatin-bound aluminum in cultured human cells. Neurotoxicology 1: 65 (1980)

88.  Sanderson, C.L., Crapper McLachlan, D.R. and DeBoni, U.; Inhibition of corticosterone binding in vitro in rabbit hippocampus, by chromatin-bound aluminum. Acta Neuropathol. 57: 249 (1982)

89.  Sanderson, C.L., McLachlan, D.R.C. and DeBoni, U.: Altered steroid induced puffing by chromatin bound aluminum in a polytene chromosome of the black fly Simulium vittatum. Can. J. Genet. Cytol. 24: 27 (1982)

90.  San-Marina, S. and Nicholls, D.M.: Some effects of aluminum on rat brain protein synthesis. Comp. Biochem. Physiol. 103C: 585 (1992)

91.  Birchall, J.D. and Chappell, J.S.: Aluminum, chemical physiology and Alzheimer’s disease. Lancet 2: 1008 (1988)

92.  Alfrey, A.C.: Aluminum intoxication, recognition, and treatment. In: Aluminum in Chemistry, Biology and Medicine (Nicolini, M. et al eds) p.73, Raven Press, New York, 1991

93.  Candy, J.M., McArthur, F.K., Oakley, A.E., Taylor, G.A., Chem, C.P.L.-H., Mountfort, S.A., Thompson, J.E., Chalker, P.R., Bishop, H.E., Beyreuther, K., Perry, G., Ward, M.K., Martyn, C.N. and Edwardson, J.A.: Aluminum accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure. J. Neurol. Set. 107: 210 (1992)

94.  Callahan, L.M., Wylen, E.L., Messer, A, and Mazurkiewiez, J.E.: Neurofilament distribution is altered in the Mnd (Motor neuron degeneration) mouse. J. Neuropathol. Exp. Neurol. 50: 491 (1991)

95.  Clauberg, M. and Joshi J.G.: Regulation of serine protease activity by aluminum: Implications for Alzheimer disease. Proc. Natl. Acad. Set USA 90: 1009 (1993)

96.  Mori, H., Kondo, J. and lhara, Y.: Ubiquitin is a component of paired helical filament in Alzheimer’s disease, Science 235: 1641 (1987)

97.  Takeda, M., Tatebayashi, Y., Tanimukai, S., Nakamura, T., Tanaka, T. and Nishimura, T,; Immunohistochemical study of microtubule-associated protein 2 and ubiquitin in chronically aluminum intoxicated rabbit brain. Acta Neuropathol. 82: 346 (1991)

98.  Crapper-McLachlan, D.R.: Aluminum and Alzheimer’s disease. Neurobiol. Aging 7: 525 (1986)

99.  Candy, J.M., Oakley, A.E., Mountfort, S.A., Taylor, G.A., Morris, C.M., Bishop, H.E. and Edwardson, J.A.: The imaging and quantification of aluminum in the human brain using dynamic secondary ion mass spectrometry (SIMS). Biol. Cell 74: 109 (1992)

100. Piccardo, P., Yanagihara, R., Garruto ,R.M., Gibbs, C.J.,Jr. and Gajdusek, D.C.: Histochemical and X-ray microanalytical localization of aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Acta Neuropathol. 77: 1 (1988)

101. Landsberg, J.P., McDonald, B. and Watt, F.: Absence of aluminum in neuritic plaque cores in Alzheimer’s disease. Nature 360: 65 (1992)

102. Good, P.F. and Perl, D.P.: Aluminum in Alzheimer’s? Nature 362: 418 (1993)

103. Kruck, T.P.A.: Aluminum-Alzheimer’s link? Nature 363: 119 (1993)

104. Jarrett, J.T. and Lansbury, P.T.,Jr.: Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer’s disease and scrapie? Cell 73: 1055 (1993)

105. Gajdusek, D.C.: Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations. J. Neuroimmunol. 20: 95 (1988)

106. Hollosi, M., Urge, L., Perczel, A., Kajtar, J., Teplan, I., Otvos, L.,Jr. and Fasman, G.D.: Metal ion-induced conformational changes of phosphorylated fragments of human neurofilament (NF-M) protein. J. Mol. Biol. 223: 673 (1992)

107. Delamarche, C.: A molecular mechanism of aluminum neurotoxicity. J. Neurochem. 60: 384 (1993)

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