| Title | Muscarinic receptor subtypes in circular muscle layer from the body of feline stomach | |
| Authors | Slobodan M. Jankovic and Dusan B. Beleslin
Department of Pharmacology, Medical Faculty Kragujevac, Serbia, SR Yugoslavia |
|
| Citation | Jankovic, S.M., Beleslin, D.B.: Muscarinic receptor subtypes in circular muscle layer from the body of feline stomach: a hypothesis, Epitheorese Klin. Farmakol. Farmakokinet. 8(2): 53-61 (1994) | |
| Publication Date | Received for publication: 5 April 1994
Accepted for publication: 5 May 1994 |
|
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | Muscarinic receptor subtypes, circular muscle, stomach, corpus, cat. | |
| Other Terms | review article | |
| Summary | Acetylcholine, carbacholi, bethanechol, pilocarpine and AHR-602 produced dose-dependent tonic contractions of isolated preparations of circular muscle layer from feline gastric corpus (p≤0.05). Bethanechol, pilocarpine and AHR-602 (in half of exposed preparations) increased the amplitude of spontaneous contractions, but their effects were not dose-dependent. Tonic contractions of isolated preparations caused by acetylcholine, bethanechol and carbachol were dose-dependently blocked by all nine muscarinic antagonists (p≤0.05). Nonselective antagonist atropine produced significant blockade (pA2 = 8.96). Among selective antagonists the most potent were M1 selective: trihexylphenidyl (pA2=9.20), hexocydium (pA2=8.94), pirenzepine (pA2=7.14) and telenzepine (pA2=7.09). M3 selective antagonists were less potent: pFHHSiD (pA2=7.98) and scopolamine butylbromide (pA2=8.38). The least potent antagonists were M2 selective: gallamine (pA2=7.32) and pancuronium (pA2=7.28). | |
| References | 1. Levine, R.R., Birdsall, N.J.M.: Subtypes of muscarinic receptors IV. Trends Pharmacol. Sci. 10 (Suppl.): (1989)
2. Mutschler, E., Feifel, R., Moser, U., Tacke, R., Wess, J., Lambrecht, G.: Muscarinic receptor subtypes. Eur. J. Pharmacol. 183 (6): 117-119 (1990) 3. Hammer, R.: Muscarinic receptors in the stomach. Scand. J. Gastroenterol. 15: 5-11 (1980) 4. Lucchesi, P.A., Romano, F.D., Scheid, C.R., Yamaguchi, H., Honeyman, T.W.: Interaction of agonists and selective antagonists with gastric smooth muscle muscarinic receptors. Naunyn-Schmiedebergs-Arch.-Pharmacol. 339 (1-2): 145-151 (1989) 5. Hanack, C., Pfeiffer, A.: Upper gastrointestinal porcine smooth muscle expresses M2 and M3 receptors. Digestion 45: 196-201 (1990) 6. Goyal, K.R.; Identification, localization and classification of muscarinic receptor subtypes in the gut. Life Sci. 43: 2209-2220 (1988) 7. Kochemasova, N.G., Shouba, M.F., Boev, K.K.: Electrical and contractile activities of the smooth muscles from the stomach in cats. C. R. Acad. Bulg. Sci. 22: 1437-1440 (1969) 8. Bowman, C.W., Rand, J.M.: Quantitative evaluation and statistical analysis of drug action. In: Textbook of Pharmacology (C.W. Bowman and J.M. Rand, eds), Ch. 41, pp. 1-48, 2nd Ed., Melbourne, 1980 9. Jahnberg, T., Abrahamsson, H., Jansson, G., Martinson, J.: Vagal gastric relaxation in the dog. Scand. J. Gastroenterol. 12: 221-224 (1977) 10. Micheletti, R., Schiavone, A., Cereda, E., Donetti, A.: Hexocyclium derivatives with a high selectivity for smooth muscle muscarinic receptors. Br. J. Pharmacol. 100: 150-152 (1990) 11. Tallarida, J.R., Cowan, A., Adler, W.M.: pA2 and receptor differentiation: a statistical analysis of competitive antagonism. Life Sci. 25: 637-654 (1979) |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1994 – ANNUAL SUBSCRIPTION 1994 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά, Γαλλικά – English, French |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|