| Title | The epilatory effects of trypsin on human skin, applied via lecithin reverse micelles | |
| Authors | E.E. Protopapa1, A. Xenakis2, S. Avramiotis2, E.V. Prodromou3 and S.M. Koukaki3
1. Technological Educational Institution of Athens, Athens, Greece 2. Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece 3. Pharmathen Ltd., Athens, Greece |
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| Citation | Protopapa, E.E., Xenakis, A., Avramiotis, S., Prodromou, E.V., Koukaki, S.M.: The epilatory effects of trypsin on human skin, applied via lecithin reverse micelles, Epitheorese Klin. Farmakol. Farmakokinet. 12(3): 101-104 (1998) | |
| Publication Date | Received for publication: 15 November 1998
Accepted for publication: 20 December 1998 |
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| Full Text Language | English | |
| Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Trypsin, epilatory effects, human skin, lecithin reverse micelles. | |
| Other Terms | review article | |
| Summary | A method of epilation using reverse micelles containing the proteolytic enzyme, trypsin, is described based on previous experimental findings on degenarative effects of proteolytic enzymes on hair follicles, and follicle stem cells of guinea pigs and mice. The method involves rubbing of the preparation on wax epilated skin and leads to removal of hair from various skin regions, such as face, shoulders, arms and legs. The many advantages of this method renders it the method of choice for hair removal in cosmetology. | |
| References | 1. Yates J.R.: Austr. J. Biol. Sci. 21: 361 (1968)
2. Protopapa E.E., Tsigonia-Primikiriou A., Stavrianeas N.G.: Effects or proteolytic enzymes papain, Chymotrypsin and trypsin on the guinea pig skin, with special reference to the hair follicle. Epitheor. Klin. Farmakof. Farmakokinet. Int. Ed. 8: 84-89 (1994) 3. Gaissert H., Protopapa E.E. et al.: Transgenic mice carrying the regulatory region of the human papilloma virus type 11 (HPVII): Their use in studying the effect of proteolytic enzymes on mouse skin hair follicles. 35 Wissenschaftliche Tagung der Gesellschaft fur Versuchs-trerkunde, Jena, 1997 4. Gaissert H., Gissman L. et al.: Regulation of HPVII gene expression in transgenic mice, in: Proceedings of the sixth FELASA symposium, O’Donoghue, P.N. (ed.), pp. 54-55. The Royal Society of Medicine Press, London, 1997 5. Unna P.G.: Beitrage zur Histologie und Entwicklungsgeschichte der menschlichen Oberhaupt und ihrer Anhangegebilde. Arch. Mikroskop. Anal. Entwickfungsmech. 2: 665-741 (1876) 6. Cotsarellis G., Sun T.-T., Lavker R.M.: Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle and skin carcinogenesis. Cell 61: 1329-1337 (1990) 7. Avramiotis S., Xenakis A., Lianos P.: Lecithin w/o microemulsions as a host for trypsin. Enzyme activity and luminescence decay studies. Progr. Colloid Polym. Sci. 100: 286-289 (1996) 8. Avramiotis S., Lianos P., Xenakis A.: Trypsin in lecithin based w/o Microemulsions. Fluorescence and enzyme activity studies. Biocatai. Biotransform. 14: 299-316 (1997) |
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