Title | ANP as a mediator of antihypertensive drug action | |
Authors | Constantine Papadopoulos¹ and Basil Kokkas²
1. 2nd Cardiology Department and 2. Laboratory of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece |
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Citation | Papadopoulos, C., Kokkas, B.: ANP as a mediator of antihypertensive drug action, Epitheorese Klin. Farmakol. Farmakokinet. 12(3): 3-8 (1998) | |
Publication Date | Received for publication: 15 September 1997
Accepted for publication: 20 September 1997 |
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Full Text Language | English | |
Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
Keywords | Arterial hypertension, angiotensin converting enzyme inhibitors, atrial natriuretic peptides, beta adrenergic blockers. | |
Other Terms | review article | |
Summary | Atrial natriuretic peptide (ANP) has a prominent role in the arterial pressure regulation and the same substance is involved in the antihypertensive action of some drugs. References data and authors’ observations derived from research protocols in patients with moderate hypertension indicate that β-adrenergic blockers as well as ACE inhibitors exert their antihypertensive action in part by increasing ANP secretion. There is also strong evidence that ANP secretion is inhibited by β1-adrenergic receptor stimulation but it is not affected by the stimulation of β2-one. On the other hand, the action of ACE inhibitors on plasma ANP levels is probably due to a reduced catabolism of this substance while an additional rote of bradykinine seems to be reasonable. | |
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