| Title | The toxicity of organophosphate and carbamate compounds towards cultured PC12 cells | |
| Authors | J. Flaskos¹, V.P. Kotsaki-Kovatsi¹ and A.J. Hargreaves²
1. Laboratory of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Macedonia, Greece 2. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, U.K. |
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| Citation | Flaskos, J., Kotsaki-Kovatsi, V.P., Hargreaves, A.J.: The toxicity of organophosphate and carbamate compounds towards cultured PC12 cells, Epitheorese Klin. Farmakol. Farmakokinet. 8(2): 73-75 (1994) | |
| Publication Date | Received for publication: 20 May 1994
Accepted for publication: 15 June 1994 |
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| Full Text Language | English | |
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| Keywords | Organophosphates, carbamates, PC12 cells, mammalian toxicity. | |
| Other Terms | review article | |
| Summary | The effects of one organophosphate (OP) compound, paraoxon (POX) and one carbamate (CM) compound, carbaryl (CML) on the proliferation of cultured rat PC12 pheochromocytoma cells were investigated. Both drugs inhibited cell proliferation in a dose-dependent manner. Virtually complete inhibition was obtained at doses of 1000 μg/ml POX and 100 μg/ml CBL. For both drugs no significant effect was found at 1 μg/ml On the basis of the IC50 values estimated from the corresponding dose-response curves, CBL was more than an order of magnitude stronger than POX in its antiproliferative/cytotoxic action in vitro and this contrasts with the fact that POX is known to be approximately 300 times more potent than CBL in its acute mammalian toxicity in vivo. It is concluded that the in vitro antiproliferative activity/toxicity of OPs and CMs is not related to AChE inhibition and may be mediated by non-cholinergic mechanisms. | |
| References | 1. Osweiler, G.D., Carson, T.L., Buck, W.B., Van Gelder, G.A.: Clinical and Diagnostic Veterinary Toxicology, pp. 298-317, Kendall/Hunt Publishing Company, Dubuque, Iowa, 1985
2. Hayes, W.J.,Jr: Pesticides Studied in Man. pp. 284-462, Williams and Wilkins, Baltimore, 1982 3. Marquis, J.K.: Non-cholinergic mechanisms of insecticide toxicity. TIPS 6: 59-60 (1985) 4. Abou-Dania, M.B., Lapadula, D.M.: Mechanisms of organophosphorous ester-induced delayed neurotoxicity: Type I and Type II. Annu. Rev. Pharmacol. Toxicol. 30: 405-440 (1990) 5. Dickoff, D.J., Gerber, O., Turowsky, Z.: Delayed neurotoxicity after ingestion of carbamate pesticide. Neurology 37: 1229-1231 (1987) 6. Dewar, A.J.: Neurotoxicity. In: Animals and Alternatives in Toxicity Testing (M. Balls, R.J. Riddell, A.N. Worden, eds), pp. 229-270, Academic Press, New York, 1983 7. Fujita, K., Lazarovici, P., Guroff, G.: Regulation of the differentiation of PC12 pheochromocytoma cells. Environ. Health Perspect. 80: 127-142 (1989) 8. Sax, N.I.: Dangerous Properties of Industrial Materials. Van Nostrand Reinhold, New York, 1979 9. Hatch, R.C.: Poisons causing nervous stimulation or depression. In: Veterinary Pharmacology and Therapeutics (N.H. Booth, L.E. Me Donald, eds). 6th Ed., pp. 1053-1101, Iowa State University Press, Ames, Iowa, 1988 10. Flaskos, J., Me Lean, W.G., Hargreaves, A.J.: The toxicity of organophosphate compounds towards cultured PC12 cells. Toxicol. Lett. (in press). |
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| Relative Papers |
Online ISSN 1011-6575
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