| Title | Immunohistochemical localization of fibronectin in human diabetic atherosclerotic capillaries | |
| Authors | Nikos Tsavaris, Manolis Agapitos, Gregory Hatzis, Agamemnon Fertakis and Panayotis Davaris
Pathology Department and Pathologic Physiology Department, School of Medicine, University of Athens, Laiko General Hospital, Athens, Greece |
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| Citation | Tsavaris, N., Agapitos, M., Hatzis, G., Fertakis, A., Davaris, P.: Immunohistochemical localization of fibronectin in human diabetic atherosclerotic capillaries, Epitheorese Klin. Farmakol. Farmakokinet. 8(2): 76-79 (1994) | |
| Publication Date | Received for publication: 1 June 1994
Accepted for publication: 30 June 1994 |
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| Full Text Language | English | |
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| Keywords | Atherosclerotic capillaries, diabetes mellitus, fibronectin. | |
| Other Terms | review article | |
| Summary | In order to investigate the frequency of fibronectin presence in atherosclerotic diabetic vessels, we examined in the post mortem material the development of fibronectin in the capillaries of diabetic patients with atherosclerosis. We established two groups of patients, group A with 20 patients without diabetes, who died of myocardial infarction and group B with 20 diabetic patients, well controlled with insulin, who also died of myocardial infarction. For the detection of fibronectin, the PAP immunohistochemical method was employed, with some slight modifications. The diabetic group presented generalized atherosclerosis, which showed, in many places, significant deposit of fibronectin. This is probably due to the rapid development of atherosclerosis in diabetus mellitus. | |
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