| Title | Drug-membrane interactions an example with the pair of anesthetic steroids alphaxalone and Δ16-alphaxalone | |
| Author | Thomas Mavromoustakos
National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, Vasileos Constantinou 48, Athens, 11635, Greece |
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| Citation | Mavromoustakos, T.: Drug-membrane interactions an example with the pair of anesthetic steroids alphaxalone and Δ16-alphaxalone, Epitheorese Klin. Farmakol. Farmakokinet. 12(3): 15-22 (1998) | |
| Publication Date | Received for publication: 10 September 1997
Accepted for publication: 20 October 1997 |
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| Full Text Language | English | |
| Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Phosphatidylcholine bilayers, anaesthetic steroids, dipalmitoyl phosphatidylcholine (DPPC), dimyristoyl phoshatidylcholine (DMPC), nuclear magnetic resonance (NMR), small angle x-ray diffraction, differential scanning calorimetry (DSC), cross polarization magic angle spinning (CP/MAS). | |
| Other Terms | review article | |
| Summary | This review article provides some experimental evidence using high resolution solid state NMR spectroscopy, small angle x-ray diffraction and differential scanning calorimetry which reveals differential effects between the two steroids alphaxalone and Δ16-alphaxalone in the membrane bilayers. To explain these differential effects a mechanism of action is proposed for these steroids which involves either direct action of these drugs on the phospholipid component of membranes or a lateral diffusion through the lipid bilayer and then action on a receptor site. These differential effects may account for their different biological activities. | |
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