Τόμος 11 (1997) – Τεύχος 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 11 (1997) – Issue 1 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

By | | B. Vannier, E. Milgrom, H. Loosfelt, I. Beau, J.F. Savouret, M. Misrahi, N. de Roux, N. Ghinea, Άρθρο επισκόπησης - Review Article, Πλήρες Κείμενο στα Αγγλικά - Full Text in English
Title Gonadotropin and thyrostimulin receptors
Authors M. Misrahi, N. de Roux, N. Ghinea, I. Beau, H. Loosfelt, B. Vannier, J.F. Savouret and E. Milgrom

Unité de Recherches Hormones et Reproduction, Institut National de la Santé et de la Recherche Médicale, Unité 135, Hôpital de Bicêtre, 94275 Le Kremlin Bicêtre Cédex, France
Citation Misrahi, M., de Roux, N., Ghinea, N., Beau, I.Losfelt, H. et al.: Gonadotropin and thyrostimulin receptors, Epitheorese Klin. Farmakol. Farmakokinet. 11(1): 13-17 (1997)
Publication Date Accepted for publication: 15 April 1997
Full Text Language English
Order – Buy  pharmakonpress[at]pharmakonpress[.]gr
Keywords Gonadotropin, thyrostimulin, receptor, cellular trafficking, Graves’ disease. 
Other Terms review article
Summary Gonadotropin and thyrostimulin receptors belong to a subgroup of G-protein coupled receptors characterized by a large extracellular domain responsible for the binding of the hormone. Soluble receptors arise from premessenger RNA alternative splicing (LH receptor) or cleavage and shedding of the ectodomain (TSH receptor). FSH and TSH receptors are restricted to the basolateral domain of their target cells. These receptors are also present in endothelial celts of target organ vessels and are involved in hormone transcytosis. Various genetic abnormalities of these receptors have been described.
References
  1. Loosfelt H, Misrahi M, Atger M, Salesse R, Vu Hai MT, Jolivet A, Guiochon-Mantel A, Sar S, Jallal B, Garnier J, Milgrom E: Cloning and sequencing of porcine LH/hCG receptor. Variants lacking transmembrane domain. Science 245: 525-528 (1989)
  2. McFarland KC, Sprengel R, Philips HS, Kohler M, Rosemblit N, Nikolics K, Segaloff DL, Seeburg PH: Lutropin-Choriogonadotropin receptor. An unusual member of the G protein-coupled receptor family. Science 245: 494-499 (1989)
  3. Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G: Cloning, sequencing and expression of the human thryrotropin (TSH) receptor: Evidence for binding of autoantibodies. Biochem. Biophys. Res. Commun. 165: 1250-1255 (1989)
  4. Misrahi M, Loosfelt H, Atger M, Sar S, Guiochon-Mantel A, Milgrom E: Cloning, sequencing and expression of human TSH receptor. Biochem. Biophys. Res. Commun. 166: 394-403 (1990)
  5. Minegish T, Nakamura K, Takakura Y, Ibuki Y, Igarashi M: Cloning and sequencing of human FSH receptor cDNA. Biochem. Biophys. Res. Commun. 175: 1125-1130 (1991)
  6. Loosfelt H, Pichon C, Jolivet A, Misrahi M, Caillou B, Jamous M, Vannier B, Milgrom E: Two subunit structure of the human TSH receptor. Proc. Natl. Acad. Sci. USA 89: 3765-3769 (1992)
  7. Vannier B, Loosfelt H, Meduri G, Pichon C, Milgrom E: Anti human FSH receptor monoclonal antibodies: Immunochemical and immunocytochemical characterization of the receptor. Biochemistry 35: 1359-1366 (1996)
  8. Vu Hai MT, Jolivet A, Jallal B, Salesse R, Bidart JM, Houilier A, Guiochon-Mantel A, Garnier J, Milgrom E: Monoclonal antibodies against LH (Luteinizing hormone) receptor. Immunochemical characterization of the receptor. Endocrinology 127: 2090-2098 (1990)
  9. Vu Hai MT, Misrahi M, Houilier A, Jolivet A, Milgrom E. Variant forms of the pig lutropin/choriogonadotropin receptor. Biochemistry 31: 8377-8383 (1992)
  10. Misrahi M, Ghinea N, Sar S, Saunier B, Jolivet A, Loosfelt H, Cerutti M, Devauchelle G, Milgrom E: Processing of the precursors of the human TSH receptor in various eucaryotic cells (human thyrocytes, transfected L cells and baculovirus infected insect cells). Eur. J. Biochem. 222: 711- 719 (1994)
  11. Couet J, Sar S, Jolivet A, Vu Hai MT, Milgrom E, Misrahi M: Shedding of human thyrotropin receptor ectodomain. In-volvement of a matrix metalloprotease. J. Biol. Chem. 271: 4545-4552 (1996)
  12. Couet J, De Bernard S, Loosfelt H, Saunier B, Milgrom E, Misrahi M: Cell surface protein disulfide-isomerase is involved in the shedding of human thyrotropin receptor ectodomain. Biochemistry 35: 14800-14805 (1996)
  13. Ghinea N, Vu Hai MT, Groyer-Picard MT, Houllier A, Schoevaert D, Milgrom E: Pathways of internalization of the hCG/LH receptor: Immunoelectron microscopic studies in Leydig cells and transfected L-Cells. J. Cell. Biol. 118: 1347- 1358 (1992)
  14. Ghinea N, Vu Hai MT, Groyer-Picard MT, Milgrom E: How protein hormones reach their target cells. Receptor- mediated transcytosis of hCG endothelial cells. J. Cell. Biol. 125: 87-97 (1994)
  15. Ghinea N, Milgrom E: Transport of protein hormones through the vascular endothelium. J. Endocrinol. 145: 1-9 (1995)
  16. Meduri G, Vu Hai MT, Jolivet A, Milgrom E: New functional zonation in the ovary as shown by immunohistochemistry of LH receptor. Endocrinology 131: 366-373 (1992)
  17. Meduri G, Vu Hai MT, Jolivet A, Takemori S, Kominami S, Driancourt MA, Milgrom E: Comparison of cellular distribution of LH receptors and steroidogenic enzymes in the porcine ovary. J. Endocrinol. 148: 435-446 (1996)
  18. Beau I, Misrahi M, Vannier B, Loosfelt H, Vu Hai MT, Pichon C, Milgrom E: Basolateral localization and transcytosis of gonadotropin and thyrostimulin receptors expressed in MDCK cells. J. Biol. Chem. in press (1997)
  19. Stow JL, de Almeida JB: Distribution and role of heterotrimeric G proteins in the secretory pathway of polarized epithelial cells. J. Cell. Set. 17: 33-39 (1993)
  20. Gross B, Misrahi M, Sar S, Milgrom E: Composite structure of the human thyrotropin receptor gene. Biochem. Biophys. Res. Commun. 177: 679-687 (1991)
  21. Rousseau-Merck MF, Misrahi M. Loosfelt H, Atger M, Milgrom E, Berger R: Assignment of the human thyroid stimulating hormone receptor (TSHR) Gene to chromosome 14931. Genomics 3: 233-236 (1990)
  22. Atger M, Misrahi M, Sar S, Le Flem L, Dessen P, Milgrom E: Structure of the human LH/CG receptor gene: unusual promoter and 5′ non coding regions. Mol. Cell. Endocrinol, 111: 113-123 (1995)
  23. Rouseau-Merck MF, Atger M, Loosfelt H, Milgrom E, Berger R: The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21- p16 is similar to that of the luteinizing hormone receptor gene. Genomics 14: 68-69 (1993)
  24. De Roux N, Misrahi M, Chatelain N, Gross B, Milgrom E: Microsatellites and PCR primers for genetics studies and genomic sequencing of the human TSH receptor gene. Mot. Cell. Endocrinol. 117: 253-256 (1996)
  25. De Roux N, Polak M, Couet J, Leger J, Czernichow P, Milgrom E, Misrahi M: Neomutaion of the TSH receptor in a neonatal hyperthyroidism. J. Clin. Endocrinol. Metab. 81: 2023-2026 (1996)
  26. De Roux N, Misrahi M, Brauner R, Houang M, Carel JC, Granier M, Le Bouc Y, Ghinea N, Boumedienne A, Toublanc, JE, Milgrom E: Four families with loss of function mutations of the TSH receptor. J. Clin. Endocrinol. Metab. 81: 4229-4235 (1996)
  27. Kremer H, Kraaij R, Toledo SPA, Post M, Fridman JB, Hayashida CY, Van Reen M, Milgrom E, Ropers HH, Mariman E, Themmen APN, Brunner HG: Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nature Genetics 9: 160-164 (1995)
  28. Kraaij R, Post M, Kremer H, Milgrom E, Epping W, Brunner HG, Grootegoed JA, Themmen APN: A missence mutation in the second transmembrane segment of the luteinizing hormone receptor causes familial male-limited precocious puberty. J. Clin. Endocrinol. Metab. 80: 3165- 3172 (1995)
  29. Aittomaki K, Lucena JLD, Pakarinen P, Sistonen P, Tapanainen J, Gromoll J, Kaskikari R, Sankila EM, Lehvaslaiho H, Engel AR, Neischlag E, Huhtaniemi I, de la Chapelle A: Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 82: 959-968 (1995)
  30. De Roux N, Shields DC, Misrahi M, Ratanachaiyavong S, McGregor AM, Milgrom E: Analysis of the TSH receptor as a candidate gene in familial Graves’ disease. J. Clin. Endocrinol. Metab. 81: 3483-3486 (1996)
  31. Meduri G, Charnaux N, Loosfelt H, Jolivet A, Spyratos F, Brailly S, Milgrom E: LH/hCG receptors in breast cancer. Cancer Res. 1997, in press
  32. Alvarado MV, Russo J, Alvarado NE, Russo IH: Human chorionic gonadotropin inhibits proliferation and induces expression of inhibin in human breast epithelial cells in vitro. In vitro Cell. Dev. Biol. 30A: 4-8 (1994)
  33. Russo J, Russo IH: Hormonally induced differentiation: a novel approach to breast cancer prevention. J. Cell. Biochem. Suppl. 22: 58-64 (1995)
  34. Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW: Crystal structure of human chorionic gonadotropin. Nature 369: 455-461 (1994)
  35. Lunardi-lskandar Y, Bryant JL, Zeman RA, Lam VH, Samaniego F, Besnier JM, Hermans P, Thierry AR, Gill P and Gallo RC: Tumorigenesis and metastasis of neoplastic Kaposi’s sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Nature 375: 64-68 (1995)
Relative Papers

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:

Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor

Συντακτικη Επιτροπή-Editorial Board

 

 

Bookmark the permalink.

Comments are closed.