| Title | Testosterone undecanoate versus mesterolone in hypogonadal male patients | |
| Authors | J. Papadimas, E. Bili, F. Papadopoulou, E. Spanos, B. Tarlatzis, B. Kokkas, G. Pangalos, J. Bontis and S. Mantalenakis
1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece |
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| Citation | Papadimas, J., Bili, E., Papadopoulou, F., Spanos, E., Tarlatzis, B. et al: Testosterone undecanoate versus mesterolone in hypogonadal male patients, Epitheorese Klin. Farmakol. Farmakokinet. 10(1): 3-8 (1996) | |
| Publication Date | Received for publication: 10 October 1995Accepted for publication: 25 October 1995 | |
| Full Text Language | English | |
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| Keywords | Testosterone undecanoate, mesterolone, hopogonadal male patients. | |
| Other Terms | review article | |
| Summary | A randomized, double-blind, group comparative study was performed in 16 hypogonadal mate patients in order to compare the effects on hormone plasma levels, on sexual activity and mental state of testosterone undecanoate (TU) and mesterolone (M). The TU-treated group consisted of 9 patients and the M-treated group consisted of 7 patients. Plasma testosterone (T), dihydrotestosterone (DHT), a-estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and dehydroepiandrosterone sulfate (DHEA-S) levels were evaluated before and during treatment with TU or M for 4 weeks. Moreover, libido, sexual activity and mental state were assessed and scored according to well accepted criteria. The daily dose of TU was 120 mg and of M 75 mg. TU induced a significant rise of T, DHT, E2 and DHEA-S, while FSH, LH and PRL levels remained unchanged. TU induced also a marked improvement of the sexual activity and mental state. | |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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