Τόμος 10 (1996) – Τεύχος 1 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 10 (1996) – Issue 1 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Nimodipine vs dihydroergocristine in the treatment of old age dementias: a blind, randomized, placebo-controlled study
Authors M. Tsolaki, K. Kapinas and A. Kazis

3rd Department of Neurology, Aristotle University of Thessaloniki, General Hospital G. Papanicolaou, Exohi, Thessaloniki, Macedonia, Greece

Citation Tsolaki, M., Kapinas, K., Kazis, A.: Nimodipine vs dihydroergocristine in the treatment of old age dementias: a blind, randomized, placebo-controlled study, Epitheorese Klin. Farmakol. Farmakokinet. 10(1): 16-24 (1996)
Publication Date Received for publication: 1996Accepted for publication: 1996
Full Text Language English
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Keywords Nimodipine, dihydroergocristine, dementias, AAMI, therapy.
Other Terms Clinical Trial
Summary In a placebo-controlled, double blind, randomized clinical study in 99 elderly patients with cognitive decline, nimodipine and dihydroegocristine were found to be therapeutically effective agents in the treatment of old age dementias. DSM-IIIR and NINCD-ADRDA criteria were used for the diagnosis of Alzheimer’s Disease. DSM-IIIR criteria were used for the diagnosis of vascular dementia. Hachinski score and CT scan were used for the differential diagnosis between Alzheimer’s Disease and Vascular dementia. MMSE, CAMCOG and FRSSD were used in the assessment before and after treatment. GDS and Hamilton scales were used to exclude patients with depression. CT scan was performed in all patients. Treatment with 45-90 mg of nimodipine administered orally in divided doses, and 6 mg of dihydroergocristine for three months in 33 patients with Alzheimer’s Disease, in 31 patients with vascular dementia and 35 patients with Age Associated Memory Impairment. Placebo was administered in the same patients for the same duration before treatment with nimodipine or dihydroergocristine. Wilcoxon matched pairs test was used for statistical analysis. Both agents prevented further significant decline in patients with Alzheimer Disease and were significant superior to an inactive placebo. Both agents improved significantly patients with Age Associated Memory impairment and Vascular dementia.
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