| Title | Antibody against angiotensin II receptor AT2 type as a tool for the study of receptor function | |
| Authors | Blanka Zelezna and Leopold Veselsky
Institute of Molecular Genetics of Prague and JIRl VELEK Institute of Organic Chemistry and Biochemistry, all Academy of Science of the Czech Republic, Prague |
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| Citation | Zelezna, B., Veselsky, L.: Antibody against angiotensin II receptor AT2 type as a tool for the study of receptor function, Epitheorese Klin. Farmakol. Farmakokinet. 11(2-3): 85-87 (1997) | |
| Publication Date | 1997 | |
| Full Text Language | English | |
| Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Angiotensin II, receptor AT2, antibody, receptor function. | |
| Other Terms | review article | |
| Introduction | There were recognized two main types of angiotensin II receptor: AT] and AT2. The blood pressure regulation and water homeostasis are connected with angiotensin II binding to AT receptors. The AT2 receptors are present mainly in embryonic tissues (1), but are found in very few organs in adulthood. Uterus and ovary are rather rich in AT2 receptors, but their role in these organs is not known. The amino acid sequence of AT2 receptor was deduced from its c-DNA structure (2). AT2 receptor is a membrane glycoprotein with seven transmembrane domains and with four extracellular and four intracellular regions. It shows only 32-35% homology with AT] receptor. | |
| References | 1. Grady et al.: J. Clin. Invest. 88: 921-933 (1991)
2. Nakajima et al.: BBRC 197: 393-399 (1993) 3. Tamm: PNAS: 5409-5413 (1988) 4. Merrifield: J. Am. Chem. Soc. 85: 2149-2154 (963) 5. Rivier et al.: J. Med. Chem. 20: 1409-1412 (1977) 6. Kaiser et al.: Anal. Biochem. 34: 595-598 (1970) 7. Zelezna et al.: Eur. J. Pharmacol. 260: 95-98 (1994) |
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Online ISSN 1011-6575
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