| Title | Relaxant effects of oxytocin and 8-L-lysine vasopressin on isolated human fallopian tubes | |
| Authors | Slobodan M. Jankovic¹, Branko A. Protic¹, Snezana V. Jankovic¹, Dusan B. Beleslin¹, Vassiliki Mirtsou-Fidani² and Athanasios G. Paradelis²
1. Department of Pharmacology, Medical Faculty, University of Kragujevac, Kragujevac, Serbia 2. Department of Pharmacology, Medical Faculty, University of Thessaloniki, Thessaloniki, Greece |
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| Citation | Jankovic, S.M., Protic, B.A., Jankovic, S.V., Beleslin, D.B., Mirtsou-Fidani, V. et al: Relaxant effects of oxytocin and 8-L-lysine vasopressin on isolated human fallopian tubes, Epitheorese Klin. Farmakol. Farmakokinet. 10(1): 33-37 (1996) | |
| Publication Date | Received for publication: 20 February 1996
Accepted for publication: 2 March 1996 |
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| Full Text Language | English | |
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| Keywords | Fallopian tubes, human, oxytocin, vasopressin, smooth muscle. | |
| Other Terms | review article | |
| Summary | In most organs, oxytocin and vasopressin produce contraction of smooth muscles. Our study examined effects of oxytocin and 8-L-lysine-vasopressin on isolated preparations of isthmic and ampullar segments of human Fallopian tube. Both oxytocin and 8-L-lysine vasopressin produced concentration-dependent relaxation of isolated preparations previously contracted by histamine, oxytocin being more potent. Considering high number of oxytocin and vasopressin receptors, confirmed by other studies, in Fallopian tubes, relaxing effects of neurohypophyseal hormones could be important for physiological transport of ova from peritoneal to uterine cavity. | |
| References | 1. Jartkovic S., Beleslin D.: Relaxant effects of oxytocin and 8-L-lysine vasopressin on guinea-pig and human gallbladder strips in vitro contracted by histamine. Digestion 48: 18-24 (1991)
2. Sato N.: Cyclic changes in sex steroids, prostaglandins and oxytocin receptors of normal Fallopian tube throughout the menstrual cycle. Nippon. Sanka. Fujinka. Gakkai. Zasshi. 40(9): 1432-8 (1988) 3. Wallace J.M., Heillwell R., Morgan P.J.: Autoradiographical localization of oxytocin binding sites on ovine oviduct. Reprod. Fertil. Dev. 3(2): 127-35 (1991) 4. Ayad V.J., Guldenaar S.E., Watties D.C.: Characterization and localization of oxytocin receptors in the uterus and oviduct of the non-pregnant ewe using on iodinated receptor antagonist. J. Endocrinol. 128(2): 187-195 (1991) 5. Ayad M.J., McGoff S.A., Wathes D.C.: Oxytocin receptors in the oviduct during the oestrous cycle of the ewe. J. Endocrinol. 124(3): 353-9 (1990) 6. Ayad V.J., Gillbert C.L., McGoff S.A., Matthews E.L., Wathes D.C.: Actions of oxytocin and vasopressin on oestrogen-induced electromyographic activity recorded from the uterus and oviduct of anoestrous ewes. Reprod. Fertil. Dev. 6(2): 203-9 (1994) 7. Maggi M., Genazzani A.D., Giannini S., Torrisi C., Baldi E., di Tomaso M., Munson M.: Vasopressin and oxytocin receptors in vagina, myometrium and oviduct of rabbits. Endocrinology 122(6): 2970-80 (1988) 8. Kitchen I.: Textbook of in vitro Practical Pharmacology, 1st ed. Blackwell Scientific Publications, Oxford, pp 153 (1984) 9. Popovic S., Piletic O., Mrsevic D., Cankovic J., LaCkovic V., Dordevic-Camba V., Japundzic M., Mujovic S. and Unkovic N.: Histologija, 1st ed. Medicinska Biblioteka, Beograd-Zajecar, pp 660 (1981) 10. Dayanithi G., Cazalis M., Nordmann J.J.: Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis. Nature. 325: 813-816 (1987) |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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