| Title | New compound: activity of 17β-hydroxy-3-aza-A-homo-4α-androsten-4-one-p-N,N-bis(2-chloroethyl)-aminophenoxy-acetate in P388 and L1210 leukemias | |
| Authors | Dimitris Catsoulacos and Panayotis Catsoulacos
Laboratory of Pharmaceutical Chemistry, Department of Pharmacy, School of Health and Sciences, University of Patras, Patra, Greece |
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| Citation | Catsoulacos, D., Catsoulacos, P.: New compound: activity of 17β-hydroxy-3-aza-A-homo-4α-androsten-4-one-p-N, N-bis(2-chloroethyl)-aminophenoxy-acetate in P388 and L1210 leukemias, Epitheorese Klin. Farmakol. Farmakokinet. 10(1): 38-40 (1996) | |
| Publication Date | Received for publication: 1 February 1996
Accepted for publication: 15 February 1996 |
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| Full Text Language | English | |
| Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Homo-aza-steroidal ester, antileukemic activity. | |
| Other Terms | review article | |
| Summary | The new compound 17β-hydroxy-3-aza-A-homo-4α-androsten-4-one-p-N,N-bis(2-chloroethyl)-aminophenoxy-acetate was prepared by reacting 4-[p-bis(2-chloroethyl)amino]phenoxy-acetyl chloride with 17β-hydroxy-A-homo-4α-androsten-4-one. The antileukemic activity of the ester was investigated in L1210 and P388 leukemias. The steroidal congener is inactive in P388 leukemia. | |
| References | 1. Catsoulacos P., Boutis L.: Aza-steroids. Beckmann rearrangement of 3β-acetoxy-5α-androstan-17-one oxime acetate with boron fluoride. Alkylating agents. Chim. Ther. 8: 215-217 (1973)
2. Wall M.E., Abernethy G.R., Carroll F.J., Taylor D.J.: The effect of some steroidal alkylating agents on experimental animal mammary tumor and leukemia systems. J. Med Chem. 12: 810-818 (1969). 3. Wampler G.L., Catsoulacos P.: Antileukemic effect of homo-aza-steroidal ester of p-bis(2-chloroethyl)aminophenylacetic acid. Cancer Treat. Rep. 61: 37-41 (1977) 4. Catsoulacos P., Politis D., Wampler G.L.: A new steroidal alkylating agent with improved activity in advanced murine leukemias. Cancer Chemother. Pharmacol. 3 : 67-70 (1970) 5. Catsoulacos P., Politis D., Wampler G.L.: Antitumor activity of homo-aza-steroidal esters of p-bis(2-chloroethyl)aminophenylacetic acid and p-bis(2-chloroethyl)aminophenylbutyric acid. Cancer Chemother. Pharmacol. 10: 129-132 (1983) 6. Catsoulacos P., Camoutsis Ch., Wampler G.L.: Effect of an homo-aza-steroidal ester in P388 and L1210 murine leukemias. Oncology 30: 59-60 (1989) 7. Catsoulacos P., Boutis L.: Antitumor activity of an homo-aza-steroidal ester of p-bis(2-chloroethyl)aminophenylacetic acid. Cancer Chemoth. Rep. 57: 365- 367 (1973) 8. Catsoulacos P.: Activity of 3(3-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenoxyacetate in experimental animal tumor and leukemia systems. Oncology 40: 240-243 (1983) 9. Catsoulacos P.: Further studies on the antineoplastic activity of 3p-hydroxy-13α-amino-13,17-seco-5α-andro-stan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenylacetate. Cancer Let. 22: 199-202 (1984) 10. Catsoulacos P.: Beckmann rearrangement of testosterone oximes. Chimika Chronica, New Series 1: 147-150 (1972). [Mazur R.H.: J. Org. Chem. 28: 248 (1963)] |
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