Τόμος 11 (1997) – Τεύχος 2 & 3 – Άρθρο 19 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 11 (1997) – Issue 2 & 3 – Article 19 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Use of molecular modeling to study superimposition of the thrombin receptor motif S42FLLR46 with its peptidomimetic analogs
Authors T. Mavromoustakos1, E. Theodoropoulou1, K. Alexopoulos2, J. Matsoukas2, M. Hollenberg3 and G.J. Moore3

1. National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, Vas. Constantinou 48, Athens 116 35 Greece

2. Department of Chemistry, University of Patras, Patra 265 00, Greece

3. Department of Pharmacology and Therapeutics, University of Calgary, Calgary Alberta, Canada T210 4N1

Citation Mavromoustakos, T., Theodoropoulou, E., Alexopoulos, K., Matsoukas, J.M., Hollenberg, M. et al.: Use of molecular modeling to study superimposition of the thrombin receptor motif S42FLLR46 with its peptidomimetic analogs, Epitheorese Klin. Farmakol. Farmakokinet. 11(2-3): 125-127 (1997)
Publication Date 1997
Full Text Language English
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Keywords Thrombin receptor, S42FLLR46, peptidomimetics analogs, molecular model.
Other Terms review article
Summary
References 1.   Vu, T.K., Hung, D.T.; Wheaton, V.I. and Coughlin, S.R. Molecular cloning of functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 1057-1068 (1991)

2.  Couglin, S.R.; Vu, T.K.; Hung, D.T. and Wheaton, V.l. Characterization of a functional thrombin receptor. J. Clin. Invest. 53: 351-355 (1992)

3.  Vouret-Craviati, V.; Van Obberghen, E.; Rasmussen U.B., Pavirani, A., Lecocq, J.P and Pouyssegur, J. Synthetic a-thrombin receptor peptides activate G-protein-coupled signalling pathways but are unable to induce mitogenesis. Mol. Biol. Cell. 3: 95-102 (1992)

4.  Vang, S.G.; Laniyounu, A.A.; Saifeddine, M.; Moore, G.J. and Hollenberg, M.D. Actions of thrombin and thrombin receptor peptide analogues in gastric and aortic smooth mus¬cle: Development of bioassays for structure-activity studies. Life Sci. 51: 1325-1332 (1992)

5.  Muramatsu, I.; Laniyonu, A.A.; Moore, G.J. and Hollenberg, M.D. Vascular actions of thrombin receptor peptide, Can. J. Physiol. Pharmacol. 70: 996-1003 (1992)

6.  Hollenberg, M.D.; Yang, S.G.; Laniyonu, A.A., Moore, G.J. and Saifeddine, M. Action of thrombin receptor polypeptide in gastric smooth muscle: Identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity. Mol. Pharmacol. 42: 186-191 (1992)

7.   Chao, B.H.; Kalkunte, S.; Magarone, J.M. and Stone, S.R. Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochem. 31: 6175- 6178 (1992)

8.  Vassalo, R.R.; Kieber-Emmons, T.; Cichowski, K. and Brass, L.F. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J. Biol. Chem. 267: 6081-6085 (1992)

9.  Tapparelli, C.; Metternich, R.; Ehrhardt, C.; Cook, N.S. Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile. TIPS 14: 366-377.

10.            Mavromoustakos.T.; De-PingYang; Theodoropoulou E., Makriyannis, A.: Studies of the conformational properties of the cannabinmimetic aminoalkylindole pravadoline using NMR and Molecular Modeling. Eur. J. Med. Chem. 30: 227- 234 (1995)

11. Mavromoustakos T.; Theodoropoulou, E.; Matsoukas, J.; Moore, G.; Smith. J.: Use of molecular modeling to study superimposition of angiotensin II with its non-peptide recep¬tor antagonists Rev. Clin. Pharmacol. 8: 137-142 (1994)

12.            Matsoukas, J.; Hondrelis, J.; Keramida, M.; Yamdagri, R.; Wu, Q.; Moore.G.; Mavromoustakos, T.; Makriyannis, A. Role of the N-terminal Domain of ANG II and [Sar1] ANG II on Conformation and Activity: NMR Evidence for Aromatic Ring Clustering and Peptide Backbone Folding Compared to [Des1,2,3] ANG II. J. Biol. Chem. 260: 5303-5312 (1994)

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