Τόμος 10 (1996) – Τεύχος 3 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 10 (1996) – Issue 2 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Antitumor activity of homo-aza-steroidal esters of p-N,N-Bis(2-chloroethyl)aminophenoxyacetic acid
Authors Panayotis Catsoulacos and Dimetrios Catsoulacos

School of Health Sciences, Department of Pharmacy, Laboratory of Pharmaceutical Chemistry, University of Patras, Patras, Greece

Citation Catsoulacos, P., Catsoulacos, D.: Antitumor activity of homo-aza-steroidal esters of p-N,N-Bis(2-chloroethyl)aminophenoxyacetic acid, Epitheorese Klin. Farmakol. Farmakokinet. 10(3): 120-126 (1996)
Publication Date Received for publication: 10 September 1996

Accepted for publication: 1 October 1996

Full Text Language English
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Keywords Homo-aza-steroidal esters of phenoxyacetic acid mustard, antitumor activity.
Other Terms review article
Summary The homo-aza-steroidal esters of carboxylic derivatives of N,N-bis(2-chtoroethyl)aniline are reviewed. In particular, we discuss the activity of the esters of homo-aza-steroids in which the p-N,N-bis(2-chloroethyl)aminophenoxyacetic acid is linked in the C-3 or C-17 position, while the lactam nucleus is in the D or A ring of the modified steroid respectively. The current literature indicates clearly that the potential of these esters is due to the synergistic activity of the lactam biotransformation processes and of the p- N,N-bis(2-chioroethyl)aminophenoxyacetic acid.
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