| Title | The specifity of the cell mediated immune defence | |
| Author | Peter C. Doherty and Rolf M. ZinkernagelNobel Prize in Physiology or Medicine for 1996 | |
| Citation | Doherty, P.C., Zinkernagel, R.M.: The specifity of the cell mediated immune defence, Epitheorese Klin. Farmakol. Farmakokinet. 10(3): 131-133 (1996) | |
| Publication Date | Received for publication: 1996Accepted for publication: 1996 | |
| Full Text Language | English | |
| Order – Buy | pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | – | |
| Other Terms | review article | |
| Summary | Peter Doherty and Rolf Zinkernagel have been awarded this year’s Nobel Prize in Physiology or Medicine for the discovery of how the immune system recognizes virus-infected cells. Their discovery has, in its tern, laid a foundation for an understanding of general mechanisms used by the cellular immune system to recognize both foreign microorganisms and self-molecules, The discovery is therefore highly relevant to clinical medicine, it relates both to efforts to strengthen the immune system response against invading microorganisms and certain forms of cancer, and to efforts to diminish the effects of autoimmune reactions in inflammatory diseases, such as rheumatic conditions, multiple sclerosis and diabetes. | |
| References | 1. Zinkernagel R.M., Doherty P.C.: Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic and semiallogeneic system. Nature 248: 701-702 (1974)2. Zinkernagel R.M., Doherty P.C.: Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature 251: 547- 548 (1974)
3. Doherty P.C., Zinkernagel R.M.: A biological role for the major histocompatibility antigens. Lancet 1406-1409 (1975) 4. Zinkernagel R.M., Doherty P.C.: MHC restricted cytotoxic T cells: Studies on the biological role of polymorphic major transplantation antigens T cell restriction specificity. Advances in Immunology 27: 51-177 (1979) |
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Online ISSN 1011-6575
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