Τόμος 13 (1999) – Τεύχος 1 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 13 (1999) – Issue 1 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title The role of sex hormones on carcinogenesis of the endometrium
Authors Paraskevi Moutsatsou and Constantine E. Sekeris

Department of Biological Chemistry University of Athens, Faculty of Medicine, 75 Mikras Asias Str., Goudi 115 27, Athens, Greece

Citation Moutsatsou, P., Sekeris, C.E.: The role of sex hormones on carcinogenesis of the endometrium, Epitheorese Klin. Farmakol. Farmakokinet. 13(1): 3-8 (1999)
Publication Date 1999
Full Text Language English
Order – Buy  Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) 

pharmakonpress[at]pharmakonpress[.]gr

Keywords Steroids, carcinogenesis, endometrium, steroid receptors, oestrogen.
Other Terms review article
Summary The role of sex hormones in cancerogenesis of the endometrium is well known, however the mechanism of hormone involvement in the malignant process is now beginning to be revealed. This is in part due to the progress in understanding the molecular mode of action of steroid hormones and the role of the steroid receptors in this process. In this review article the structure and structure/function relationships of the sex steroid receptors will be presented as well as the current concepts on the molecular action of steroid hormones. The cellular factors involved in the physiological cell replication process and the effects of sex hormones, by way of their receptors, on the expression of these factors, will be briefly described. The derangement of the normal regulation of the cell cycle, leading to the malignant state, by mutations induced by carcinogens will be discussed.
References 1.   Strauss F.I.I.I., Gurpide E: The Endometrium. Regulation and Dysfunction. In: (Yen S.S.C., Tafle R.B., eds) Reproductive Endocronology, WB Saunders Company, Philadelphia PA. 1991

2.  Evans R.M.: The steroid and thyroid hormone receptor superfamily. Science 240: 889-895 (1988)

3.  Parker M.G.: Steroid and related receptor. Cun. Opin. Cell Biol. 5: 499-504 (1993)

4.  Misrahi M., Atger M., d’Ayriol L., Loosfelt H., Merielc, Fridlansky F., Guiochon-Mantel A., Galibert F., Milgrom E.: Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem. Biophys. Res. Comm. 143: 740-748 (1987)

5.  Green S., Chambon P.: The oestrogen receptor: from perception to mechanism. In: (Parker M.G., ed.) Nuclear Hormone Receptors, pp. 15-38, Academic Press, London, 1991

6.  Kuiper G.G.J.M., Enmark E., Peltofluikko M., Nilsson S., Gustafsson J.A.: Cloning of novel estrogen receptor expressed in rat prostate. Proc. Natl. Acad. Sci. USA 93: 5925-5930 (1996)

7.   Wen D.X., Xu Y.F., Mais D.E., Goldman M.E., McDonnell D.P.: The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol. Cell Biol. 14: 8356-8364 (1994)

8.  Smith D.F., Toft D.O.: Steroid receptors and their associated proteins. Mol. Endocrinol. 7: 4-11 (1993)

9.  Beato M., Herrlich P., Schütz G.: Steroid hormone receptors: many actors in search of a plot. Cell 83: 851- 857 (1995)

10.            Yang-Yen H.F., Chambard J.C., Sun Y.L., Smeal T., Schmidt T., Drouin J., Karin M.: Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62: 1205-1215 (1990)

11. Aurichio E.: Phosphorylation of steroid receptors. J. Steroid. Biochem. 32: 613-622 (1989)

12.            Yang N.N., Venugopalan M., Hardikar S., Glasebrook A.: Identification of an estrogen response element activated by metabolites of 17β-estradiol and raloxifene. Science 273: 1222-1225 (1996)

13.            Moudgil V.K.: Phosphorylation of steroid hormone receptors. Biochim. Biophys. Acta loss: 243-258 (1990)

14.            Papamichail M., loannidis C., Tsawdaroglou N., Sekeris C.E.: Translocation of glucococrticoid receptor from the cytoplasm into the nucleus of phytohemagglutinin-stimulated human lymphocytes in the absence of the hormone. Expt. Cell. Res. 133: 461-465 (1981)

15.            Denner L.A., Weigel N.L., Maxwell B.L., Schrader W.T., O’Malley B.W.: Regulation of progesterone receptor-mediated transcription by phosphorylation. Science 250: 1740-1743 (1990)

16.            Power R.F., Mani S.K., Codina J., Conneely D.M., O’Malley B.: Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 254: 1636-1639 (1991)

17. Woolley D.E., Hope W.G., Thompson-Reece M.A., Gietzen D.W., Conway S.B.: Dopaminergic stimulation of estrogen receptor binding in vivo. A reexamination. Recent Progr. Hormone Res. 49: 383-392 (1994)

18.            Joel P.B., Traish A.M., Lannigan D.A.: Estradiol and phorbol ester cause phoshorylation of serine 118 in the human estrogen receptor. Mot. Endocrinol. 9: 1041-1052 (1995).

19.            Ignar-Trobridge D.M., Nelson K.R., Bidwell M.C., Curtis S.W., Washburn T.F., McLachlan J.A., Korach K.: Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. Proc. Natl. Acad. Sci. USA 89: 4658-4662 (1992)

20.            Beato M., Sanchez-Pacheco A.: Interaction of steroid hormone receptors with the transcription initiation complex. Endocr. Rev. 17: 587-609 (1996)

21.            Ignar-Trobridge D.M., Teng C.T., Ross K.A., Parker M.G., Korach K.S., McLachlan J.A.: Peptide growth factors elicit estrogen-dependent transcriptional activation of an estrogen-responsive element. Mol. Endocrinol 7: 992-998 (1993)

22.            Weisz A., Bresciani F.: Estrogen induces expression of c-fos and c-myc proto-oncogenes in rat uterus. Mot. Endocrinol. 2: 816-824 (1988)

23.            Chiappetta C., Kirkland J.C., Loose-Mitchell D.S., Murthy L., Stance! G.M.: Estrogen regulates expression of the jun family of proto-oncogenes in the uterus. J. Steroid Biochem. Mol. Biol. 41: 113-123 (1992)

24.            Weisz A., Rosales R.: Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Res. 18: 5097-5106 (1990)

25.            Hyder S.M., Nawaz Z., Chiappetta C., Yokoyama K., Stancel G.M.: The protoncogene c-jun contains an unusual estrogen-inducibie enhancer within the coding sequence. J. Biol. Chem. 270: 8506-8513 (1995)

26.            Zachos G., Zoumpourlis V., Sekeris C.E., Spandidos D.A.: Binding of the glucocorticoid and estrogen receptor to the human H-ras oncogene sequences, Int. J. Oncol. 6: 595-600 (1995)

27.            Kirkland J.L., Murthy L., Stancel G.M.: Progesterone inhibits the estrogen-induced expression of c-fos messenger ribonucleic acid in the uterus. Endocrinology 130: 3223-3230 (1992)

28.            Beato M.: Gene regulation by steroid hormones. Cell 56: 335-344 (1989)

29.            Sekeris C.E.: Hormonal steroids act as tumor promoters by modulating oncogene expression. J. Cancer Res. Clin. Oncol. 117: 96-101 (1991)

30.            Schuchard M., Landers J.P., Punkay-Sandhu N., Spelsberg T.C.: Steroid hormone regulation of nuclear protooncogenes. Endocr. Rev. 14: 659-669 (1993)

31.            Bamberger A.M., Bamberger C.M., Gellersen B., Schulte H.M.: Modulation of AP-1 activity by the human progesterone receptor in endometrial adenocarcinoma cells. Proc. Natl. Acad. Sci. USA 93: 6169-6174 (1996)

Relative Papers

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:

Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor

Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση-Οδηγίες προς τους Συγγραφείς – 
What is Epitheorese Klinikes Farmakologias 
και Farmakokinetikes-International Edition-Instrunctions to Authors

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – 
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 1999 – ANNUAL SUBSCRIPTION 1999
Γλώσσα Πλήρους Κειμένου – Full Text Language Αγγλικά – English
Παραγγελία – Αγορά – Order – Buy Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)

pharmakonpress[at]pharmakonpress[.]gr

Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)

pharmakonpress[at]pharmakonpress[.]gr

 

 

 

 

Bookmark the permalink.

Comments are closed.